Sphingomyelin Phosphodiesterase
"Sphingomyelin Phosphodiesterase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide (N-acylsphingosine) plus choline phosphate. A defect in this enzyme leads to NIEMANN-PICK DISEASE. EC 3.1.4.12.
| Descriptor ID |
D013108
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| MeSH Number(s) |
D08.811.277.352.640.750
|
| Concept/Terms |
Sphingomyelin Phosphodiesterase- Sphingomyelin Phosphodiesterase
- Sphingomyelin Cleaving Enzyme
- Sphingomyelinase C
- Sphingomyelinase
- Sphingomyelin Cholinephosphohydrolase
|
Below are MeSH descriptors whose meaning is more general than "Sphingomyelin Phosphodiesterase".
Below are MeSH descriptors whose meaning is more specific than "Sphingomyelin Phosphodiesterase".
This graph shows the total number of publications written about "Sphingomyelin Phosphodiesterase" by people in this website by year, and whether "Sphingomyelin Phosphodiesterase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 5 | 2 | 7 |
| 2018 | 2 | 1 | 3 |
| 2020 | 1 | 0 | 1 |
| 2021 | 2 | 1 | 3 |
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Below are the most recent publications written about "Sphingomyelin Phosphodiesterase" by people in Profiles.
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SARS-CoV-2 infection induces the activation of tissue factor-mediated coagulation via activation of acid sphingomyelinase. Blood. 2021 07 29; 138(4):344-349.
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Association Between FIASMAs and Reduced Risk of Intubation or Death in Individuals Hospitalized for Severe COVID-19: An Observational Multicenter Study. Clin Pharmacol Ther. 2021 12; 110(6):1498-1511.
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Differential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells. J Gen Virol. 2021 05; 102(5).
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Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells. J Biol Chem. 2021 Jan-Jun; 296:100701.
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Repurposing functional inhibitors of acid sphingomyelinase (fiasmas): an opportunity against SARS-CoV-2 infection? J Clin Pharm Ther. 2021 Oct; 46(5):1213-1219.
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Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetine. Emerg Microbes Infect. 2020 Dec; 9(1):2245-2255.
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Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells. Cell Rep Med. 2020 11 17; 1(8):100142.
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Nuclear Lipid Microdomains Regulate Daunorubicin Resistance in Hepatoma Cells. Int J Mol Sci. 2018 Nov 01; 19(11).
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Reactive oxygen species mediates 50-Hz magnetic field-induced EGF receptor clustering via acid sphingomyelinase activation. Int J Radiat Biol. 2018 07; 94(7):678-684.
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Nitric Oxide Generated by Tumor-Associated Macrophages Is Responsible for Cancer Resistance to Cisplatin and Correlated With Syntaxin 4 and Acid Sphingomyelinase Inhibition. Front Immunol. 2018; 9:1186.