"Cytochrome P-450 CYP11B2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of CORTICOSTERONE to 18-hydroxycorticosterone and the subsequent conversion to ALDOSTERONE.
Descriptor ID |
D019405
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MeSH Number(s) |
D08.244.453.484.500 D08.244.453.915.050 D08.811.682.690.708.170.425.500 D08.811.682.690.708.170.915.050 D12.776.422.220.453.484.500 D12.776.422.220.453.915.050
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Concept/Terms |
Cytochrome P-450 CYP11B2- Cytochrome P-450 CYP11B2
- Cytochrome P 450 CYP11B2
- Aldosterone Synthase
- Aldosterone Synthase Cytochrome P-450
- Aldosynthase
- Cytochrome P450Aldo
- P450c11AS
- Cytochrome P450 11B2
- Cytochrome P-450c11AS
- Cytochrome P 450c11AS
- CYP11B2
- Steroid 18-Hydroxylase
- Steroid 18 Hydroxylase
- CYP 11B2
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Below are MeSH descriptors whose meaning is more general than "Cytochrome P-450 CYP11B2".
Below are MeSH descriptors whose meaning is more specific than "Cytochrome P-450 CYP11B2".
This graph shows the total number of publications written about "Cytochrome P-450 CYP11B2" by people in this website by year, and whether "Cytochrome P-450 CYP11B2" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2007 | 0 | 1 | 1 |
2011 | 1 | 0 | 1 |
2013 | 1 | 0 | 1 |
2017 | 2 | 0 | 2 |
2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cytochrome P-450 CYP11B2" by people in Profiles.
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Future pharmacological therapy in hypertension. Curr Opin Cardiol. 2018 07; 33(4):408-415.
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Impact of Aldosterone Synthase Inhibitor FAD286 on Steroid Hormone Profile in Human Adrenocortical Cells. Horm Metab Res. 2017 Sep; 49(9):701-706.
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The Aldosterone Synthase Inhibitor FAD286 is Suitable for Lowering Aldosterone Levels in ZDF Rats but not in db/db Mice. Horm Metab Res. 2017 Jun; 49(6):466-471.
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Genetic predisposition to left ventricular hypertrophy and the potential involvement of cystatin-C in untreated hypertension. Am J Hypertens. 2013 May; 26(5):683-90.
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Genetic polymorphism of CYP11B2 gene and stroke in the Han Chinese population and a meta-analysis. Pharmacogenet Genomics. 2011 Mar; 21(3):115-20.
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Adrenocortical changes and arterial hypertension in lipoatrophic A-ZIP/F-1 mice. Mol Cell Endocrinol. 2008 Jan 02; 280(1-2):39-46.