Multidrug Resistance-Associated Proteins
"Multidrug Resistance-Associated Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the ATP-BINDING CASSETTE, SUB-FAMILY B, MEMBER 1 family of proteins.
| Descriptor ID |
D027425
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| MeSH Number(s) |
D12.776.157.530.100.304 D12.776.157.530.450.074.500.500.500 D12.776.543.585.100.304 D12.776.543.585.450.074.500.500.500
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| Concept/Terms |
Multidrug Resistance-Associated Proteins- Multidrug Resistance-Associated Proteins
- Multidrug Resistance Associated Proteins
- Multispecific Organic Anion Transporter
- Multispecific Organic Anion Transport Proteins
- ATP-Binding Cassette, Sub-Family C Proteins
- ATP Binding Cassette, Sub Family C Proteins
- MOAT Protein
- Multidrug Resistance-Associated Protein
- Multidrug Resistance Associated Protein
- Resistance-Associated Protein, Multidrug
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Below are MeSH descriptors whose meaning is more general than "Multidrug Resistance-Associated Proteins".
Below are MeSH descriptors whose meaning is more specific than "Multidrug Resistance-Associated Proteins".
This graph shows the total number of publications written about "Multidrug Resistance-Associated Proteins" by people in this website by year, and whether "Multidrug Resistance-Associated Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 4 | 4 | 8 |
| 2018 | 5 | 3 | 8 |
| 2019 | 1 | 1 | 2 |
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Below are the most recent publications written about "Multidrug Resistance-Associated Proteins" by people in Profiles.
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Molecular detection of drug resistant polymorphisms in Plasmodium falciparum isolates from Southwest, Nigeria. BMC Res Notes. 2020 Oct 27; 13(1):497.
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Diagnostic value of soluble mesothelin-related peptides in pleural effusion for malignant pleural mesothelioma: An updated meta-analysis. Medicine (Baltimore). 2019 Apr; 98(14):e14979.
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Proof of an Outer Membrane Target of the Efflux Inhibitor Phe-Arg-ß-Naphthylamide from Random Mutagenesis. Molecules. 2019 Jan 29; 24(3).
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Platelet miRNA-26b down-regulates multidrug resistance protein 4 in patients on chronic aspirin treatment. J Cardiovasc Med (Hagerstown). 2018 10; 19(10):611-613.
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Genetic polymorphisms in candidate genes are not associated with increased vincristine-related peripheral neuropathy in Arab children treated for acute childhood leukemia: a single institution study. Pharmacogenet Genomics. 2018 08; 28(8):189-195.
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Revisiting the role of ABC transporters in multidrug-resistant cancer. Nat Rev Cancer. 2018 07; 18(7):452-464.
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Resveratrol mediated cancer cell apoptosis, and modulation of multidrug resistance proteins and metabolic enzymes. Phytomedicine. 2019 Mar 01; 55:269-281.
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Effect of ABCC2 and ABCG2 Gene Polymorphisms and CSF-to-Serum Albumin Ratio on Ceftriaxone Plasma and Cerebrospinal Fluid Concentrations. J Clin Pharmacol. 2018 12; 58(12):1550-1556.
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Prevalence and correlates of persistent intracellular HIV transcription in individuals on efavirenz versus atazanavir-based regimens: A prospective cohort study. PLoS One. 2018; 13(3):e0194262.
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Attaching NorA efflux pump inhibitors to methylene blue enhances antimicrobial photodynamic inactivation of Escherichia coli and Acinetobacter baumannii in vitro and in vivo. Bioorg Med Chem Lett. 2018 09 01; 28(16):2736-2740.