"MAP Kinase Kinase 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitogen-activated protein kinase kinase with specificity for JNK MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES and the RETINOID X RECEPTORS. It takes part in a SIGNAL TRANSDUCTION pathway that is activated in response to cellular stress.
| Descriptor ID |
D048670
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| MeSH Number(s) |
D08.811.913.696.620.682.700.565.400 D08.811.913.696.620.682.725.200.400 D12.644.360.440.400 D12.776.476.440.400
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| Concept/Terms |
MAP Kinase Kinase 4- MAP Kinase Kinase 4
- JN Kinase Kinase
- JNK Kinase
- Jun Amino-Terminal Kinase Kinase
- Jun Amino Terminal Kinase Kinase
- JNK-Activating Protein Kinase
- JNK Activating Protein Kinase
- Protein Kinase, JNK-Activating
- SAP Kinase-Extracellular Signal-Regulated Kinase Kinase 1
- SAP Kinase Extracellular Signal Regulated Kinase Kinase 1
- SEK1 Protein Kinase
- Protein Kinase, SEK1
- Mitogen-Activated Protein Kinase Kinase 4
- Mitogen Activated Protein Kinase Kinase 4
- MEK4 Protein Kinase
- Protein Kinase, MEK4
- JNKK1 Protein Kinase
- Kinase, JNKK1 Protein
- Protein Kinase, JNKK1
- Stress-Activated Protein Kinase Kinase 1
- Stress Activated Protein Kinase Kinase 1
- SAPK-ERK Kinase 1
- SAPK ERK Kinase 1
- SAP Kinase Kinase 1
|
Below are MeSH descriptors whose meaning is more general than "MAP Kinase Kinase 4".
Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Kinase 4".
This graph shows the total number of publications written about "MAP Kinase Kinase 4" by people in this website by year, and whether "MAP Kinase Kinase 4" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2017 | 1 | 3 | 4 |
| 2018 | 2 | 6 | 8 |
| 2019 | 1 | 1 | 2 |
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Below are the most recent publications written about "MAP Kinase Kinase 4" by people in Profiles.
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Thymulin and peroxiredoxin 6 have protective effects against streptozotocin-induced type 1 diabetes in mice. Int J Immunopathol Pharmacol. 2021 Jan-Dec; 35:20587384211005645.
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The DPP-4 inhibitor saxagliptin ameliorates ox-LDL-induced endothelial dysfunction by regulating AP-1 and NF-?B. Eur J Pharmacol. 2019 May 15; 851:186-193.
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TNF-a Drives the CCL4 Expression in Human Monocytic Cells: Involvement of the SAPK/JNK and NF-?B Signaling Pathways. Cell Physiol Biochem. 2019; 52(4):908-921.
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Resveratrol attenuates the MSU crystal-induced inflammatory response through the inhibition of TAK1 activity. Int Immunopharmacol. 2019 Feb; 67:62-68.
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Sevoflurane relieves hepatic ischemia-reperfusion injury by inhibiting the expression of Grp78. Biosci Rep. 2018 10 31; 38(5).
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FKBP11 protects intestinal epithelial cells against inflammation-induced apoptosis via the JNK-caspase pathway in Crohn's disease. Mol Med Rep. 2018 Nov; 18(5):4428-4438.
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Sirt1 Protects against Oxidative Stress-Induced Apoptosis in Fibroblasts from Psoriatic Patients: A New Insight into the Pathogenetic Mechanisms of Psoriasis. Int J Mol Sci. 2018 May 25; 19(6).
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Lactic Acid Downregulates Viral MicroRNA To Promote Epstein-Barr Virus-Immortalized B Lymphoblastic Cell Adhesion and Growth. J Virol. 2018 05 01; 92(9).
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Juglone induces apoptosis and autophagy via modulation of mitogen-activated protein kinase pathways in human hepatocellular carcinoma cells. Food Chem Toxicol. 2018 Jun; 116(Pt B):40-50.
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miR-126-5p by direct targeting of JNK-interacting protein-2 (JIP-2) plays a key role in Theileria-infected macrophage virulence. PLoS Pathog. 2018 03; 14(3):e1006942.