"Apolipoprotein E4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.
| Descriptor ID |
D053327
|
| MeSH Number(s) |
D10.532.091.500.750 D12.776.070.400.500.750 D12.776.521.120.500.750
|
| Concept/Terms |
Apolipoprotein E4- Apolipoprotein E4
- Apolipoprotein E-4
- Apolipoprotein E 4
- Apo E4
- ApoE4
- Apo E epsilon 4
- Apo E-4
- Apo E 4
|
Below are MeSH descriptors whose meaning is more general than "Apolipoprotein E4".
Below are MeSH descriptors whose meaning is more specific than "Apolipoprotein E4".
This graph shows the total number of publications written about "Apolipoprotein E4" by people in this website by year, and whether "Apolipoprotein E4" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 11 | 6 | 17 |
| 2018 | 6 | 4 | 10 |
| 2019 | 1 | 3 | 4 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Apolipoprotein E4" by people in Profiles.
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Association of Apolipoprotein e polymorphism with SARS-CoV-2 infection. Infect Genet Evol. 2021 11; 95:105043.
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Severe COVID-19 in Alzheimer's disease: APOE4's fault again? Alzheimers Res Ther. 2021 Jun 12; 13(1):111.
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Apolipoprotein E4 Allele in Subjects with COVID-19. Gerontology. 2021; 67(3):320-322.
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COVID-19 enters the expanding network of apolipoprotein E4-related pathologies. Redox Biol. 2021 05; 41:101938.
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Could COVID-19 anosmia and olfactory dysfunction trigger an increased risk of future dementia in patients with ApoE4? Med Hypotheses. 2021 Feb; 147:110479.
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Effects of COVID-19 Home Confinement on Mental Health in Individuals with Increased Risk of Alzheimer's Disease. J Alzheimers Dis. 2021; 79(3):1015-1021.
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Coronavirus disease 2019, multisystem inflammatory syndrome in children, apolipoprotein E4, and race. J Pediatr. 2021 02; 229:313-314.
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Neurobiochemical Cross-talk Between COVID-19 and Alzheimer's Disease. Mol Neurobiol. 2021 Mar; 58(3):1017-1023.
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APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort. J Gerontol A Biol Sci Med Sci. 2020 10 15; 75(11):2231-2232.
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Lipoprotein(a) and Its Potential Association with Thrombosis and Inflammation in COVID-19: a Testable Hypothesis. Curr Atheroscler Rep. 2020 07 25; 22(9):48.