"Lysosomes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture is supposed to be under metabolic (hormonal) control. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
Descriptor ID |
D008247
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MeSH Number(s) |
A11.284.430.214.190.875.190.550
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Lysosomes".
Below are MeSH descriptors whose meaning is more specific than "Lysosomes".
This graph shows the total number of publications written about "Lysosomes" by people in this website by year, and whether "Lysosomes" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1997 | 1 | 0 | 1 |
2005 | 0 | 1 | 1 |
2010 | 0 | 1 | 1 |
2013 | 0 | 1 | 1 |
2014 | 2 | 0 | 2 |
2016 | 1 | 1 | 2 |
2017 | 6 | 12 | 18 |
2018 | 5 | 17 | 22 |
2019 | 3 | 10 | 13 |
2020 | 1 | 5 | 6 |
2021 | 3 | 4 | 7 |
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Below are the most recent publications written about "Lysosomes" by people in Profiles.
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[Induced degradation of proteins by PROTACs and other strategies: towards promising drugs]. Biol Aujourdhui. 2021; 215(1-2):25-43.
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TMEM106B in humans and Vac7 and Tag1 in yeast are predicted to be lipid transfer proteins. Proteins. 2022 01; 90(1):164-175.
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The Molecular Interplay between Human Coronaviruses and Autophagy. Cells. 2021 08 07; 10(8).
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[This way out! SARS-CoV-2 takes the lysosomal pathway]. Med Sci (Paris). 2021 Aug-Sep; 37(8-9):716-719.
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Manipulation of autophagy by SARS-CoV-2 proteins. Autophagy. 2021 09; 17(9):2659-2661.
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Recombinant SARS-CoV-2 envelope protein traffics to the trans-Golgi network following amphipol-mediated delivery into human cells. J Biol Chem. 2021 08; 297(2):100940.
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Activation of mTORC1 at late endosomes misdirects T cell fate decision in older individuals. Sci Immunol. 2021 06 18; 6(60).
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The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-?. Proc Natl Acad Sci U S A. 2021 06 08; 118(23).
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Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion. Exp Mol Med. 2021 05; 53(5):956-972.
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The Discovery of Naringenin as Endolysosomal Two-Pore Channel Inhibitor and Its Emerging Role in SARS-CoV-2 Infection. Cells. 2021 05 07; 10(5).