Cholesterol 7-alpha-Hydroxylase
"Cholesterol 7-alpha-Hydroxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP7, converts cholesterol to 7-alpha-hydroxycholesterol which is the first and rate-limiting step in the synthesis of BILE ACIDS.
| Descriptor ID |
D002790
|
| MeSH Number(s) |
D08.244.453.890.500 D08.244.453.915.200 D08.811.682.690.708.170.890.500 D08.811.682.690.708.170.915.200 D12.776.422.220.453.890.500 D12.776.422.220.453.915.200
|
| Concept/Terms |
Cholesterol 7-alpha-Hydroxylase- Cholesterol 7-alpha-Hydroxylase
- Cholesterol 7 alpha Hydroxylase
- Cholesterol 7alpha-Hydroxylase
- Cholesterol 7alpha Hydroxylase
- Cholesterol-7-Hydroxylase
- Cholesterol 7 Hydroxylase
- Cytochrome P-450 CYP7
- Cytochrome P 450 CYP7
- CYP7A
- Cholesterol 7-alpha-Monooxygenase
- Cholesterol 7 alpha Monooxygenase
- Cytochrome P450 7
- CYP7
- CYP 7A
- CYP 7
|
Below are MeSH descriptors whose meaning is more general than "Cholesterol 7-alpha-Hydroxylase".
Below are MeSH descriptors whose meaning is more specific than "Cholesterol 7-alpha-Hydroxylase".
This graph shows the total number of publications written about "Cholesterol 7-alpha-Hydroxylase" by people in this website by year, and whether "Cholesterol 7-alpha-Hydroxylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cholesterol 7-alpha-Hydroxylase" by people in Profiles.
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The Epidermal Growth Factor Receptor Ligand Amphiregulin Protects From Cholestatic Liver Injury and Regulates Bile Acids Synthesis. Hepatology. 2019 04; 69(4):1632-1647.
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EP4 emerges as a novel regulator of bile acid synthesis and its activation protects against hypercholesterolemia. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 09; 1863(9):1029-1040.
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Prostaglandin E2 promotes hepatic bile acid synthesis by an E prostanoid receptor 3-mediated hepatocyte nuclear receptor 4a/cholesterol 7a-hydroxylase pathway in mice. Hepatology. 2017 03; 65(3):999-1014.