"Complement Factor H" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An important soluble regulator of the alternative pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It is a 139-kDa glycoprotein expressed by the liver and secreted into the blood. It binds to COMPLEMENT C3B and makes iC3b (inactivated complement 3b) susceptible to cleavage by COMPLEMENT FACTOR I. Complement factor H also inhibits the association of C3b with COMPLEMENT FACTOR B to form the C3bB proenzyme, and promotes the dissociation of Bb from the C3bBb complex (COMPLEMENT C3 CONVERTASE, ALTERNATIVE PATHWAY).
| Descriptor ID |
D017242
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| MeSH Number(s) |
D12.776.124.486.274.920.325.200 D12.776.124.790.223.200 D12.776.377.715.182.200
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Complement Factor H".
Below are MeSH descriptors whose meaning is more specific than "Complement Factor H".
This graph shows the total number of publications written about "Complement Factor H" by people in this website by year, and whether "Complement Factor H" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2017 | 2 | 3 | 5 |
| 2018 | 1 | 6 | 7 |
| 2019 | 1 | 3 | 4 |
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Below are the most recent publications written about "Complement Factor H" by people in Profiles.
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COVID-19 vaccines induce severe hemolysis in paroxysmal nocturnal hemoglobinuria. Blood. 2021 07 01; 137(26):3670-3673.
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Mini-Factor H Modulates Complement-Dependent IL-6 and IL-10 Release in an Immune Cell Culture (PBMC) Model: Potential Benefits Against Cytokine Storm. Front Immunol. 2021; 12:642860.
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Genetic justification of severe COVID-19 using a rigorous algorithm. Clin Immunol. 2021 05; 226:108726.
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Case Report: Severe Complement-Mediated Thrombotic Microangiopathy in IgG4-Related Disease Secondary to Anti-Factor H IgG4 Autoantibodies. Front Immunol. 2020; 11:604759.
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Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition. Blood. 2020 10 29; 136(18):2080-2089.
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Response to Comment on "Self versus Nonself Discrimination by the Soluble Complement Regulators Factor H and FHL-1". J Immunol. 2019 10 15; 203(8):2029-2030.
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Terminal complement effectors in atypical hemolytic uremic syndrome: C5a, C5b-9, or a bit of both? Kidney Int. 2019 07; 96(1):13-15.
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Clinical and Immunological Profile of Anti-factor H Antibody Associated Atypical Hemolytic Uremic Syndrome: A Nationwide Database. Front Immunol. 2019; 10:1282.
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Rare Functional Variants in Complement Genes and Anti-FH Autoantibodies-Associated aHUS. Front Immunol. 2019; 10:853.
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Membrane Attack Complex and Factor H in Humans with Acute Kidney Injury. Kidney Blood Press Res. 2018; 43(5):1655-1665.