"Dactinomycin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
| Descriptor ID |
D003609
|
| MeSH Number(s) |
D03.633.300.200 D04.345.566.252 D12.644.641.252
|
| Concept/Terms |
Cosmegen- Cosmegen
- Cosmegen Lyovac
- Lyovac, Cosmegen
- Lyovac-Cosmegen
- Lyovac Cosmegen
- LyovacCosmegen
|
Below are MeSH descriptors whose meaning is more general than "Dactinomycin".
Below are MeSH descriptors whose meaning is more specific than "Dactinomycin".
This graph shows the total number of publications written about "Dactinomycin" by people in this website by year, and whether "Dactinomycin" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dactinomycin" by people in Profiles.
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Differential TBXA2 receptor transcript stability is dependent on the C924T polymorphism. Prostaglandins Other Lipid Mediat. 2018 01; 134:141-147.
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SARS-coronavirus replication/transcription complexes are membrane-protected and need a host factor for activity in vitro. PLoS Pathog. 2008 May 02; 4(5):e1000054.
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Differential in vitro inhibition of feline enteric coronavirus and feline infectious peritonitis virus by actinomycin D. J Gen Virol. 1992 Dec; 73 ( Pt 12):3285-8.
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Monoclonal antibody analysis of a unique macrophage procoagulant activity induced by murine hepatitis virus strain 3 infection. J Biol Chem. 1991 Jan 25; 266(3):1789-95.
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Cellular and metabolic requirements for induction of macrophage procoagulant activity by murine hepatitis virus strain 3 in vitro. J Immunol. 1991 Jan 01; 146(1):271-8.
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Natural resistance of mice to mouse hepatitis virus type 3 infection is expressed in embryonic fibroblast cells. J Gen Virol. 1984 Jul; 65 ( Pt 7):1165-71.
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Berne virus is not 'coronavirus-like'. J Gen Virol. 1984 Mar; 65 ( Pt 3):645-9.
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RNA-dependent RNA polymerase activity in murine coronavirus-infected cells. J Gen Virol. 1983 Jan; 64 (Pt 1):103-11.
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The virus-specific intracellular RNA species of two murine coronaviruses: MHV-a59 and MHV-JHM. Virology. 1981 Oct 15; 114(1):39-51.
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Host cell nuclear function and murine hepatitis virus replication. J Gen Virol. 1981 Oct; 56(Pt 2):457-60.