"Gene Products, nef" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Products of the retroviral NEF GENE. They play a role as accessory proteins that influence the rate of viral infectivity and the destruction of the host immune system. nef gene products were originally found as factors that trans-suppress viral replication and function as negative regulators of transcription. nef stands for negative factor.
| Descriptor ID |
D015693
|
| MeSH Number(s) |
D12.776.964.775.362 D12.776.964.925.500
|
| Concept/Terms |
Gene Products, nef- Gene Products, nef
- Gene Product, nef
- nef Gene Product
- nef Protein
- 3'-orf Protein
- 3' orf Protein
- nef Gene Products
|
Below are MeSH descriptors whose meaning is more general than "Gene Products, nef".
Below are MeSH descriptors whose meaning is more specific than "Gene Products, nef".
This graph shows the total number of publications written about "Gene Products, nef" by people in this website by year, and whether "Gene Products, nef" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 2006 | 1 | 1 | 2 |
| 2008 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2017 | 1 | 1 | 2 |
| 2018 | 4 | 0 | 4 |
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Below are the most recent publications written about "Gene Products, nef" by people in Profiles.
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Preadaptation of Simian Immunodeficiency Virus SIVsmm Facilitated Env-Mediated Counteraction of Human Tetherin by Human Immunodeficiency Virus Type 2. J Virol. 2018 09 15; 92(18).
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SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue. PLoS Pathog. 2018 08; 14(8):e1007269.
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Mamu-B*17+ Rhesus Macaques Vaccinated with env, vif, and nef Manifest Early Control of SIVmac239 Replication. J Virol. 2018 08 15; 92(16).
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Viral protein Nef is detected in plasma of half of HIV-infected adults with undetectable plasma HIV RNA. PLoS One. 2018; 13(1):e0191613.
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Unlocking HIV-1 Env: implications for antibody attack. AIDS Res Ther. 2017 Sep 12; 14(1):42.
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Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3. Nat Commun. 2017 09 05; 8(1):442.
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Tetherin antagonism by primate lentiviral nef proteins. Curr HIV Res. 2011 Oct; 9(7):514-23.
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Design, construction, and characterization of a dual-promoter multigenic DNA vaccine directed against an HIV-1 subtype C/B' recombinant. J Acquir Immune Defic Syndr. 2008 Apr 01; 47(4):403-11.
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Innate anti-viral immunity is associated with the protection elicited by the simian immunodeficiency virus (SIV) live attenuated virus vaccine in cynomolgus monkeys. Med Sci Monit. 2006 Oct; 12(10):BR330-40.
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The Nef protein of human immunodeficiency virus is a broad-spectrum modulator of chemokine receptor cell surface levels that acts independently of classical motifs for receptor endocytosis and Galphai signaling. Mol Biol Cell. 2006 Aug; 17(8):3578-90.