"Multigene Family" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
| Descriptor ID |
D005810
|
| MeSH Number(s) |
G05.360.340.024.340.645
|
| Concept/Terms |
Multigene Family- Multigene Family
- Families, Multigene
- Family, Multigene
- Multigene Families
Gene Clusters- Gene Clusters
- Cluster, Gene
- Clusters, Gene
- Gene Cluster
|
Below are MeSH descriptors whose meaning is more general than "Multigene Family".
Below are MeSH descriptors whose meaning is more specific than "Multigene Family".
This graph shows the total number of publications written about "Multigene Family" by people in this website by year, and whether "Multigene Family" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 2 | 2 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 3 | 1 | 4 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 1 | 2 | 3 |
| 2017 | 11 | 14 | 25 |
| 2018 | 10 | 14 | 24 |
| 2019 | 0 | 6 | 6 |
| 2020 | 0 | 3 | 3 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Multigene Family" by people in Profiles.
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Viral fibrotic scoring and drug screen based on MAPK activity uncovers EGFR as a key regulator of COVID-19 fibrosis. Sci Rep. 2021 05 27; 11(1):11234.
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Filling in the Gaps in Metformin Biodegradation: a New Enzyme and a Metabolic Pathway for Guanylurea. Appl Environ Microbiol. 2021 05 11; 87(11).
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SARS-CoV-2 mutations: the biological trackway towards viral fitness. Epidemiol Infect. 2021 04 30; 149:e110.
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Key genetic elements, single and in clusters, underlying geographically dependent SARS-CoV-2 genetic adaptation and their impact on binding affinity for drugs and immune control. J Antimicrob Chemother. 2021 01 19; 76(2):396-412.
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Chromosome 3 cluster rs11385942 variant links complement activation with severe COVID-19. J Autoimmun. 2021 02; 117:102595.
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Genetic mechanisms of critical illness in COVID-19. Nature. 2021 03; 591(7848):92-98.
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The major genetic risk factor for severe COVID-19 is inherited from Neanderthals. Nature. 2020 11; 587(7835):610-612.
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SARS Coronavirus-2 variant tracing within the first Coronavirus Disease 19 clusters in northern Germany. Clin Microbiol Infect. 2021 Jan; 27(1):130.e5-130.e8.
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Genomewide Association Study of Severe Covid-19 with Respiratory Failure. N Engl J Med. 2020 10 15; 383(16):1522-1534.
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Genome-wide identification and classification of MIKC-type MADS-box genes in Streptophyte lineages and expression analyses to reveal their role in seed germination of orchid. BMC Plant Biol. 2019 May 28; 19(1):223.