"Factor XIIa" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.
| Descriptor ID |
D015956
|
| MeSH Number(s) |
D08.811.277.656.300.760.324 D08.811.277.656.959.350.324 D12.776.124.125.450.324 D23.119.450.324
|
| Concept/Terms |
Factor XIIa- Factor XIIa
- Activated Factor XII
- Factor XII, Activated
- Coagulation Factor XIIa
- Factor XIIa, Coagulation
- Blood Coagulation Factor XII, Activated
- Prekallikrein Activator
- Activator, Prekallikrein
- Factor Twelve A
- Factor 12A
|
Below are MeSH descriptors whose meaning is more general than "Factor XIIa".
Below are MeSH descriptors whose meaning is more specific than "Factor XIIa".
This graph shows the total number of publications written about "Factor XIIa" by people in this website by year, and whether "Factor XIIa" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Factor XIIa" by people in Profiles.
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Thromboplasminflammation in COVID-19 Coagulopathy: Three Viewpoints for Diagnostic and Therapeutic Strategies. Front Immunol. 2021; 12:649122.
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Age-dependent possible role of contact-activated blood coagulation factor XII as a potential contributor to the “bradykinin storm” in COVID-19 patients Orv Hetil. 2020 12 13; 161(50):2099-2103.
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Understanding the Pathophysiology of COVID-19: Could the Contact System Be the Key? Front Immunol. 2020; 11:2014.
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Anticoagulation With an Inhibitor of Factors XIa and XIIa During Cardiopulmonary Bypass. J Am Coll Cardiol. 2019 10 29; 74(17):2178-2189.
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The polyphosphate-factor XII pathway drives coagulation in prostate cancer-associated thrombosis. Blood. 2015 Sep 10; 126(11):1379-89.