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Codon, Nonsense

"Codon, Nonsense" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition

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An amino acid-specifying codon that has been converted to a stop codon (CODON, TERMINATOR) by mutation. Its occurance is abnormal causing premature termination of protein translation and results in production of truncated and non-functional proteins. A nonsense mutation is one that converts an amino acid-specific codon to a stop codon.

Descriptor ID	D018389
MeSH Number(s)	D13.444.735.544.355.250.235 G05.360.335.355.250.235 G05.365.590.195
Concept/Terms	Codon, Nonsense Codon, Nonsense Premature Termination Codon Codon, Premature Termination Codons, Premature Termination Premature Termination Codons Termination Codon, Premature Termination Codons, Premature Premature Stop Codon Codon, Premature Stop Codons, Premature Stop Premature Stop Codons Stop Codon, Premature Stop Codons, Premature Nonsense Codon Codons, Nonsense Nonsense Codons Codon, Termination, Premature Mutation, Nonsense Mutation, Nonsense Mutations, Nonsense Nonsense Mutations Nonsense Mutation Ochre Nonsense Codon Ochre Nonsense Codon Codon, Ochre Nonsense Codons, Ochre Nonsense Nonsense Codon, Ochre Nonsense Codons, Ochre Ochre Nonsense Codons Ochre Nonsense Mutation Ochre Nonsense Mutation Mutation, Ochre Nonsense Mutations, Ochre Nonsense Nonsense Mutation, Ochre Nonsense Mutations, Ochre Ochre Nonsense Mutations Amber Nonsense Mutation Amber Nonsense Mutation Amber Nonsense Mutations Mutation, Amber Nonsense Mutations, Amber Nonsense Nonsense Mutation, Amber Nonsense Mutations, Amber Opal Nonsense Mutation Opal Nonsense Mutation Mutation, Opal Nonsense Mutations, Opal Nonsense Nonsense Mutation, Opal Nonsense Mutations, Opal Opal Nonsense Mutations Amber Nonsense Codon Amber Nonsense Codon Amber Nonsense Codons Codon, Amber Nonsense Codons, Amber Nonsense Nonsense Codons, Amber Nonsense Codon, Amber Codon, Unassigned Codon, Unassigned Codons, Unassigned Unassigned Codons Unassigned Codon Opal Nonsense Codon Opal Nonsense Codon Codon, Opal Nonsense Codons, Opal Nonsense Nonsense Codon, Opal Nonsense Codons, Opal Opal Nonsense Codons

Below are MeSH descriptors whose meaning is more general than "Codon, Nonsense".

Chemicals and Drugs [D]
Nucleic Acids, Nucleotides, and Nucleosides [D13]
Nucleic Acids [D13.444]
RNA [D13.444.735]
RNA, Messenger [D13.444.735.544]
Codon [D13.444.735.544.355]
Codon, Terminator [D13.444.735.544.355.250]
Codon, Nonsense [D13.444.735.544.355.250.235]
Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Genetic Code [G05.360.335]
Codon [G05.360.335.355]
Codon, Terminator [G05.360.335.355.250]
Codon, Nonsense [G05.360.335.355.250.235]
Genetic Variation [G05.365]
Mutation [G05.365.590]
Codon, Nonsense [G05.365.590.195]

Below are MeSH descriptors whose meaning is more specific than "Codon, Nonsense".

Publications

Timeline | Most Recent

This graph shows the total number of publications written about "Codon, Nonsense" by people in this website by year, and whether "Codon, Nonsense" was a major or minor topic of these publications.

Bar chart showing 27 publications over 8 distinct years, with a maximum of 11 publications in 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	1	0	1
2009	1	1	2
2010	1	0	1
2013	1	0	1
2017	3	5	8
2018	3	8	11
2019	1	1	2
2020	0	1	1

Below are the most recent publications written about "Codon, Nonsense" by people in Profiles.

Causes and Consequences of Purifying Selection on SARS-CoV-2. Genome Biol Evol. 2021 10 01; 13(10).

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SARS-CoV-2 variants lacking ORF8 occurred in farmed mink and pangolin. Gene. 2021 Jun 05; 784:145596.

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SARS-CoV-2 variants combining spike mutations and the absence of ORF8 may be more transmissible and require close monitoring. Biochem Biophys Res Commun. 2021 04 23; 550:8-14.

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The SARS-CoV-2 ORF10 is not essential in vitro or in vivo in humans. PLoS Pathog. 2020 12; 16(12):e1008959.

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SARS-CoV-2 ORF3b Is a Potent Interferon Antagonist Whose Activity Is Increased by a Naturally Occurring Elongation Variant. Cell Rep. 2020 09 22; 32(12):108185.

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Evolutionary dynamics of the SARS-CoV-2 ORF8 accessory gene. Infect Genet Evol. 2020 11; 85:104525.

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Aminoglycosides can be a better choice over macrolides in COVID-19 regimen: Plausible mechanism for repurposing strategy. Med Hypotheses. 2020 Nov; 144:109984.

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A Novel Nonsense Angiogenin Mutation is Associated With Alzheimer Disease. Alzheimer Dis Assoc Disord. 2019 Apr-Jun; 33(2):163-165.

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Long-Term Outcome of WHIM Syndrome in 18 Patients: High Risk of Lung Disease and HPV-Related Malignancies. J Allergy Clin Immunol Pract. 2019 May - Jun; 7(5):1568-1577.

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A novel LMNA nonsense mutation causes two distinct phenotypes of cardiomyopathy with high risk of sudden cardiac death in a large five-generation family. Europace. 2018 12 01; 20(12):2003-2013.

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Pyrc, Krzysztof

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Codon, Nonsense