Mitogen-Activated Protein Kinase 1
"Mitogen-Activated Protein Kinase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. Activation of the enzyme by phosphorylation leads to its translocation into the nucleus where it acts upon specific transcription factors. p40 MAPK and p41 MAPK are isoforms.
| Descriptor ID |
D019950
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.567.249.500 D12.644.360.450.169.500 D12.776.476.450.169.500
|
| Concept/Terms |
Mitogen-Activated Protein Kinase 1- Mitogen-Activated Protein Kinase 1
- Mitogen Activated Protein Kinase 1
- p42 MAPK
- p42(Mitogen-Activated Protein Kinase)
- p42(Mapk) Kinase
- p42 MAP Kinase
- MAP Kinase, p42
- MAPK2 Mitogen-Activated Protein Kinase
- MAPK2 Mitogen Activated Protein Kinase
- Extracellular Signal-Regulated Kinase 2
- Extracellular Signal Regulated Kinase 2
- Mitogen-Activated Protein Kinase 2
- Mitogen Activated Protein Kinase 2
- MAPK1 Mitogen-Activated Protein Kinase
- MAPK1 Mitogen Activated Protein Kinase
- p42(Mapk)
- MAP Kinase 2
|
Below are MeSH descriptors whose meaning is more general than "Mitogen-Activated Protein Kinase 1".
Below are MeSH descriptors whose meaning is more specific than "Mitogen-Activated Protein Kinase 1".
This graph shows the total number of publications written about "Mitogen-Activated Protein Kinase 1" by people in this website by year, and whether "Mitogen-Activated Protein Kinase 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 6 | 8 | 14 |
| 2018 | 3 | 6 | 9 |
| 2019 | 1 | 1 | 2 |
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Below are the most recent publications written about "Mitogen-Activated Protein Kinase 1" by people in Profiles.
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Selective targeting of the inactive state of hematopoietic cell kinase (Hck) with a stable curcumin derivative. J Biol Chem. 2021 Jan-Jun; 296:100449.
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Investigating the mechanism of ShuFeng JieDu capsule for the treatment of novel Coronavirus pneumonia (COVID-19) based on network pharmacology. Int J Med Sci. 2020; 17(16):2511-2530.
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Characterization of Kcnk3-Mutated Rat, a Novel Model of Pulmonary Hypertension. Circ Res. 2019 09 13; 125(7):678-695.
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The m6A-suppressed P2RX6 activation promotes renal cancer cells migration and invasion through ATP-induced Ca2+ influx modulating ERK1/2 phosphorylation and MMP9 signaling pathway. J Exp Clin Cancer Res. 2019 Jun 03; 38(1):233.
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The ER stress sensor IRE1 and MAP kinase ERK modulate autophagy induction in cells infected with coronavirus infectious bronchitis virus. Virology. 2019 07; 533:34-44.
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DS-70, a novel and potent a4 integrin antagonist, is an effective treatment for experimental allergic conjunctivitis in guinea pigs. Br J Pharmacol. 2018 10; 175(20):3891-3910.
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Extracellular loop 3 substitutions K589N and A590S in FSH receptor increase FSH-induced receptor internalization and along with S588T substitution exhibit impaired ERK1/2 phosphorylation. Arch Biochem Biophys. 2018 12 01; 659:57-65.
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Synthesis of novel 1,2-bis-quinolinyl-1,4-naphthoquinones: ERK2 inhibition, cytotoxicity and molecular docking studies. Bioorg Chem. 2018 12; 81:700-712.
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Matrix stiffness regulates the differentiation of tendon-derived stem cells through FAK-ERK1/2 activation. Exp Cell Res. 2018 12 15; 373(1-2):62-70.
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EP4 emerges as a novel regulator of bile acid synthesis and its activation protects against hypercholesterolemia. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 09; 1863(9):1029-1040.