"Calcium Channels, L-Type" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.
| Descriptor ID |
D020746
|
| MeSH Number(s) |
D12.776.157.530.400.150.400 D12.776.543.550.450.150.400 D12.776.543.585.400.150.400
|
| Concept/Terms |
Calcium Channels, L-Type- Calcium Channels, L-Type
- Calcium Channels, L Type
- L-Type VDCC
- L Type VDCC
- VDCC, L-Type
- L-Type Calcium Channel
- Calcium Channel, L-Type
- L Type Calcium Channel
- L-Type Voltage-Dependent Calcium Channels
- L Type Voltage Dependent Calcium Channels
- L-Type Calcium Channels
- L Type Calcium Channels
- Long-Lasting Calcium Channels
- Calcium Channels, Long-Lasting
- Long Lasting Calcium Channels
Receptors, Dihydropyridine- Receptors, Dihydropyridine
- L-Type VDCC alpha-1 Subunit
- L Type VDCC alpha 1 Subunit
- Dihydropyridine Receptor
- Receptor, Dihydropyridine
- Dihydropyridine Receptors
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Below are MeSH descriptors whose meaning is more general than "Calcium Channels, L-Type".
Below are MeSH descriptors whose meaning is more specific than "Calcium Channels, L-Type".
This graph shows the total number of publications written about "Calcium Channels, L-Type" by people in this website by year, and whether "Calcium Channels, L-Type" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 2 | 3 | 5 |
| 2018 | 1 | 3 | 4 |
| 2019 | 1 | 3 | 4 |
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Below are the most recent publications written about "Calcium Channels, L-Type" by people in Profiles.
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Amyloid-Beta Modulates Low-Threshold Activated Voltage-Gated L-Type Calcium Channels of Arcuate Neuropeptide Y Neurons Leading to Calcium Dysregulation and Hypothalamic Dysfunction. J Neurosci. 2019 10 30; 39(44):8816-8825.
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Putative role of Brugada syndrome genes in familial atrial fibrillation. Eur Rev Med Pharmacol Sci. 2019 Sep; 23(17):7582-7598.
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Calcium channel blockers reduce severe fever with thrombocytopenia syndrome virus (SFTSV) related fatality. Cell Res. 2019 Sep; 29(9):739-753.
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Involvement of calcium in 50-Hz magnetic field-induced activation of sphingosine kinase 1 signaling pathway. Bioelectromagnetics. 2019 Apr; 40(3):180-187.
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Neurobiology of the major psychoses: a translational perspective on brain structure and function-the FOR2107 consortium. Eur Arch Psychiatry Clin Neurosci. 2019 Dec; 269(8):949-962.
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A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. Elife. 2018 06 20; 7.
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A Sialylated Voltage-Dependent Ca2+ Channel Binds Hemagglutinin and Mediates Influenza A Virus Entry into Mammalian Cells. Cell Host Microbe. 2018 06 13; 23(6):809-818.e5.
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Application of Multigene Panel Sequencing in Patients with Prolonged Rate-corrected QT Interval and No Pathogenic Variants Detected in KCNQ1, KCNH2, and SCN5A. Ann Lab Med. 2018 Jan; 38(1):54-58.
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Proteolytic cleavage and PKA phosphorylation of a1C subunit are not required for adrenergic regulation of CaV1.2 in the heart. Proc Natl Acad Sci U S A. 2017 08 22; 114(34):9194-9199.
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Genetic Testing in the Evaluation of Unexplained Cardiac Arrest: From the CASPER (Cardiac Arrest Survivors With Preserved Ejection Fraction Registry). Circ Cardiovasc Genet. 2017 Jun; 10(3).