"Semaphorins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of proteins that mediate AXONAL GUIDANCE. Semaphorins act as repulsive cues for neuronal GROWTH CONES and bind to receptors on their filopodia. At least 20 different molecules have been described and divided into eight classes based on domain organization and species of origin. Classes 1 and 2 are invertebrate, classes 3-7 are vertebrate, and class V are viral. Semaphorins may be secreted (classes 2, 3, and V), transmembrane (classes 1, 4, 5, and 6), or membrane-anchored (class 7). All semaphorins possess a common 500-amino acid extracellular domain which is critical for receptor binding and specificity, and is also found in plexins and scatter factor receptors. Their C termini are class-specific and may contain additional sequence motifs.
Descriptor ID |
D039961
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MeSH Number(s) |
D12.644.276.923 D12.776.467.923 D23.529.923
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Semaphorins".
Below are MeSH descriptors whose meaning is more specific than "Semaphorins".
This graph shows the total number of publications written about "Semaphorins" by people in this website by year, and whether "Semaphorins" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2015 | 1 | 0 | 1 |
2017 | 1 | 0 | 1 |
2018 | 1 | 1 | 2 |
2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Semaphorins" by people in Profiles.
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MMP2/MMP9-mediated CD100 shedding is crucial for inducing intrahepatic anti-HBV CD8 T cell responses and HBV clearance. J Hepatol. 2019 10; 71(4):685-698.
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RNA sequencing to predict response to TNF-a inhibitors reveals possible mechanism for nonresponse in smokers. Expert Rev Clin Immunol. 2018 07; 14(7):623-633.
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Semaphorin 4D correlates with increased bone resorption, hypercalcemia, and disease stage in newly diagnosed patients with multiple myeloma. Blood Cancer J. 2018 05 11; 8(5):42.
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Shear stress-regulated miR-27b controls pericyte recruitment by repressing SEMA6A and SEMA6D. Cardiovasc Res. 2017 May 01; 113(6):681-691.
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Plexin-D1/Semaphorin 3E pathway may contribute to dysregulation of vascular tone control and defective angiogenesis in systemic sclerosis. Arthritis Res Ther. 2015 Aug 21; 17:221.