"Tetanus Toxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.
| Descriptor ID |
D013744
|
| MeSH Number(s) |
D12.776.097.872 D23.946.123.893
|
| Concept/Terms |
Tetanus Toxin- Tetanus Toxin
- Toxin, Tetanus
- Clostridium tetani Toxin
- Toxin, Clostridium tetani
- Tetanus Toxins
- Toxins, Tetanus
|
Below are MeSH descriptors whose meaning is more general than "Tetanus Toxin".
Below are MeSH descriptors whose meaning is more specific than "Tetanus Toxin".
This graph shows the total number of publications written about "Tetanus Toxin" by people in this website by year, and whether "Tetanus Toxin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 0 | 2 | 2 |
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Below are the most recent publications written about "Tetanus Toxin" by people in Profiles.
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Does tetanus vaccination contribute to reduced severity of the COVID-19 infection? Med Hypotheses. 2021 Jan; 146:110395.
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Isolation and Characterization of Antigen-Specific Plasmablasts Using a Novel Flow Cytometry-Based Ig Capture Assay. J Immunol. 2017 12 15; 199(12):4180-4188.
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Conjugate Vaccines from Bacterial Antigens by Squaric Acid Chemistry: A Closer Look. Chembiochem. 2017 04 18; 18(8):799-815.
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A Cholera Conjugate Vaccine Containing O-specific Polysaccharide (OSP) of V. cholerae O1 Inaba and Recombinant Fragment of Tetanus Toxin Heavy Chain (OSP:rTTHc) Induces Serum, Memory and Lamina Proprial Responses against OSP and Is Protective in Mice. PLoS Negl Trop Dis. 2015; 9(7):e0003881.
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New advances in the production of edible plant vaccines: chloroplast expression of a tetanus vaccine antigen, TetC. Phytochemistry. 2004 Apr; 65(8):989-94.