"DNA Gyrase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Gyrase binds to DNA as a heterotetramer consisting of two A and two B subunits. In the presence of ATP, gyrase is able to convert the relaxed circular DNA duplex into a superhelix. In the absence of ATP, supercoiled DNA is relaxed by DNA gyrase.
| Descriptor ID |
D027081
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| MeSH Number(s) |
D08.811.399.403.741.149 D12.776.097.237
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "DNA Gyrase".
Below are MeSH descriptors whose meaning is more specific than "DNA Gyrase".
This graph shows the total number of publications written about "DNA Gyrase" by people in this website by year, and whether "DNA Gyrase" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 4 | 8 | 12 |
| 2018 | 2 | 3 | 5 |
| 2019 | 1 | 4 | 5 |
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Below are the most recent publications written about "DNA Gyrase" by people in Profiles.
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Improved determination of Neisseria gonorrhoeae gyrase A genotype results in clinical specimens. J Antimicrob Chemother. 2019 10 01; 74(10):2913-2915.
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Moxifloxacin resistance and genotyping of Mycobacterium avium and Mycobacterium intracellulare isolates in Japan. J Infect Chemother. 2019 Dec; 25(12):995-1000.
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Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes. Nature. 2019 07; 571(7763):72-78.
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Epidemiology of Clostridium difficile infection in hospitalized adults and the first isolation of C. difficile PCR ribotype 027 in central China. BMC Infect Dis. 2019 Mar 07; 19(1):232.
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A multisite implementation of a real-time polymerase chain reaction assay to predict ciprofloxacin susceptibility in Neisseria gonorrhoeae. Diagn Microbiol Infect Dis. 2019 Jul; 94(3):213-217.
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Biology-Oriented Drug Synthesis (BIODS) Approach towards Synthesis of Ciprofloxacin-Dithiocarbamate Hybrids and Their Antibacterial Potential both in Vitro and in Silico. Chem Biodivers. 2018 Oct; 15(10):e1800273.
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Fusobacterium necrophorum Subsp. funduliforme in Tonsils from Various Patient Populations in Japan. Jpn J Infect Dis. 2018 Sep 21; 71(5):365-367.
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Ciprofloxacin May be Efficacious in Treating Wild-Type Gyrase A Genotype Neisseria gonorrhoeae Infections. Sex Transm Dis. 2018 04; 45(4):e18.
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Emergence of multidrug-resistant sequence type 45 strains among mecA-positive borderline oxacillin-resistant Staphylococcus aureus causing bacteraemia in a medical centre in Taiwan. Int J Antimicrob Agents. 2018 Jul; 52(1):70-75.
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A Cost Analysis of Gyrase A Testing and Targeted Ciprofloxacin Therapy Versus Recommended 2-Drug Therapy for Neisseria gonorrhoeae Infection. Sex Transm Dis. 2018 02; 45(2):87-91.