"Receptor, PAR-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A G-protein-coupled, proteinase-activated receptor that is expressed in a variety of tissues including ENDOTHELIUM; LEUKOCYTES; and the GASTROINTESTINAL TRACT. The receptor is activated by TRYPSIN, which cleaves off the N-terminal peptide from the receptor. The new N-terminal peptide is a cryptic ligand for the receptor. The uncleaved receptor can also be activated by the N-terminal peptide present on the activated THROMBIN RECEPTOR and by small synthetic peptides that contain the unmasked N-terminal sequence.
| Descriptor ID |
D044464
|
| MeSH Number(s) |
D12.776.543.750.695.035 D12.776.543.750.792.249
|
| Concept/Terms |
Receptor, PAR-2- Receptor, PAR-2
- Receptor, PAR 2
- Trypsin Receptors
- Receptors, Trypsin
- Trypsin Receptor
- PAR2 Receptor
- Receptor, PAR2
- Proteinase Activated Receptor 2
- Protease-Activated Receptor 2
- Protease Activated Receptor 2
- Receptor 2, Protease-Activated
- Receptor, Trypsin
- PAR-2 Receptor
- PAR 2 Receptor
|
Below are MeSH descriptors whose meaning is more general than "Receptor, PAR-2".
Below are MeSH descriptors whose meaning is more specific than "Receptor, PAR-2".
This graph shows the total number of publications written about "Receptor, PAR-2" by people in this website by year, and whether "Receptor, PAR-2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2017 | 3 | 0 | 3 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Receptor, PAR-2" by people in Profiles.
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Disruption of the biological activity of protease-activated receptors2/4 in adults rather than children in SARS CoV-2 virus-mediated mortality in COVID-19 infection. Drug Dev Res. 2021 12; 82(8):1075-1078.
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Trypsin-Like Proteases and Their Role in Muco-Obstructive Lung Diseases. Int J Mol Sci. 2021 May 29; 22(11).
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Protease-activated receptor 2 deficiency mediates cardiac fibrosis and diastolic dysfunction. Eur Heart J. 2019 10 21; 40(40):3318-3332.
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Protease-Activated Receptor 2 Facilitates Bacterial Dissemination in Pneumococcal Pneumonia. J Infect Dis. 2018 04 11; 217(9):1462-1471.
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Protease-activated receptor 2 activates airway apical membrane chloride permeability and increases ciliary beating. FASEB J. 2018 01; 32(1):155-167.
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Protease-activated receptor-2 promotes kidney tubular epithelial inflammation by inhibiting autophagy via the PI3K/Akt/mTOR signalling pathway. Biochem J. 2017 08 02; 474(16):2733-2747.
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Stress induces more serious barrier dysfunction in follicle-associated epithelium than villus epithelium involving mast cells and protease-activated receptor-2. Sci Rep. 2017 07 10; 7(1):4950.
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PAR-2 activating peptide-induced stimulation of pregnant rat myometrium contractile activity partly involves the other membrane receptors. Eur J Obstet Gynecol Reprod Biol. 2007 Jan; 130(1):51-9.
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Protease-activated receptor-1 in human lung fibroblasts mediates a negative feedback downregulation via prostaglandin E2. Am J Physiol Lung Cell Mol Physiol. 2005 May; 288(5):L793-802.