Proliferating Cell Nuclear Antigen
"Proliferating Cell Nuclear Antigen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
Descriptor ID |
D018809
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MeSH Number(s) |
D12.776.660.740 D23.050.290.750 D23.101.140.600
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Proliferating Cell Nuclear Antigen".
Below are MeSH descriptors whose meaning is more specific than "Proliferating Cell Nuclear Antigen".
This graph shows the total number of publications written about "Proliferating Cell Nuclear Antigen" by people in this website by year, and whether "Proliferating Cell Nuclear Antigen" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2003 | 0 | 1 | 1 |
2005 | 0 | 1 | 1 |
2017 | 0 | 5 | 5 |
2018 | 0 | 6 | 6 |
2019 | 2 | 1 | 3 |
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Below are the most recent publications written about "Proliferating Cell Nuclear Antigen" by people in Profiles.
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Inhibition of the NKp44-PCNA Immune Checkpoint Using a mAb to PCNA. Cancer Immunol Res. 2019 07; 7(7):1120-1134.
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Protective effect of the glucagon-like peptide-1 analogue liraglutide on carbon tetrachloride-induced acute liver injury in mice. Biochem Biophys Res Commun. 2019 06 25; 514(2):386-392.
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NDRG1 facilitates the replication and persistence of Kaposi's sarcoma-associated herpesvirus by interacting with the DNA polymerase clamp PCNA. PLoS Pathog. 2019 02; 15(2):e1007628.
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The Ethanol Supernatant Extracts of Liushenwan Could Alleviate Nanodiethylnitrosamine-Induced Liver Cancer in Mice. Can J Gastroenterol Hepatol. 2018; 2018:6934809.
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POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication. Mol Cell. 2018 10 04; 72(1):112-126.e5.
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Role of Sirolimus in renal tubular apoptosis in response to unilateral ureteral obstruction. Int J Med Sci. 2018; 15(13):1433-1442.
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Blood Pressure Measurement and Hypertension Diagnosis in the 2017 US Guidelines: First Things First. Hypertension. 2018 06; 71(6):963-965.
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Treatment Thresholds and Targets in Hypertension: Different Readings of the Same Evidence? Hypertension. 2018 06; 71(6):966-968.
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APE2 promotes DNA damage response pathway from a single-strand break. Nucleic Acids Res. 2018 03 16; 46(5):2479-2494.
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SPOCD1 promotes cell proliferation and inhibits cell apoptosis in human osteosarcoma. Mol Med Rep. 2018 Feb; 17(2):3218-3225.