"Leukocyte Elastase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with greater specificity for Ala. EC 3.4.21.37.
| Descriptor ID |
D019272
|
| MeSH Number(s) |
D08.811.277.656.300.760.560.500 D08.811.277.656.959.350.560.500
|
| Concept/Terms |
Leukocyte Elastase- Leukocyte Elastase
- Elastase, Leukocyte
- Polymorphonuclear Leukocyte Elastase
- Elastase, Polymorphonuclear Leukocyte
- Leukocyte Elastase, Polymorphonuclear
- Neutrophil Elastase
- Elastase, Neutrophil
- PMN Elastase
- Elastase, PMN
- Granulocyte Elastase
- Elastase, Granulocyte
- Lysosomal Elastase
- Elastase, Lysosomal
|
Below are MeSH descriptors whose meaning is more general than "Leukocyte Elastase".
Below are MeSH descriptors whose meaning is more specific than "Leukocyte Elastase".
This graph shows the total number of publications written about "Leukocyte Elastase" by people in this website by year, and whether "Leukocyte Elastase" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 5 | 3 | 8 |
| 2018 | 2 | 2 | 4 |
| 2021 | 2 | 1 | 3 |
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Below are the most recent publications written about "Leukocyte Elastase" by people in Profiles.
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Flavonoids as inhibitors of human neutrophil elastase. J Enzyme Inhib Med Chem. 2021 Dec; 36(1):1016-1028.
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Inhibition of elastase enhances the adjuvanticity of alum and promotes anti-SARS-CoV-2 systemic and mucosal immunity. Proc Natl Acad Sci U S A. 2021 08 24; 118(34).
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Neutrophil Extracellular Traps (NETs) in Severe SARS-CoV-2 Lung Disease. Int J Mol Sci. 2021 Aug 17; 22(16).
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Evolution of NETosis markers and DAMPs have prognostic value in critically ill COVID-19 patients. Sci Rep. 2021 08 03; 11(1):15701.
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Anti-Inflammatory, Antiallergic, and COVID-19 Main Protease (Mpro) Inhibitory Activities of Butenolides from a Marine-Derived Fungus Aspergillus terreus. Molecules. 2021 Jun 02; 26(11).
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SARS-CoV-2 Infection in a Child with Severe Congenital Neutropenia. J Clin Immunol. 2021 08; 41(6):1165-1168.
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Protease-antiprotease imbalance in patients with severe COVID-19. Clin Chem Lab Med. 2021 07 27; 59(8):e330-e334.
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SARS-CoV-2 mutation 614G creates an elastase cleavage site enhancing its spread in high AAT-deficient regions. Infect Genet Evol. 2021 06; 90:104760.
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Hypothesis: Alpha-1-antitrypsin is a promising treatment option for COVID-19. Med Hypotheses. 2021 Jan; 146:110394.
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Anti-protease Treatments Targeting Plasmin(ogen) and Neutrophil Elastase May Be Beneficial in Fighting COVID-19. Physiol Rev. 2020 10 01; 100(4):1597-1598.