"Founder Effect" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phenomenon that is observed when a small subgroup of a larger POPULATION establishes itself as a separate and isolated entity. The subgroup's GENE POOL carries only a fraction of the genetic diversity of the parental population resulting in an increased frequency of certain diseases in the subgroup, especially those diseases known to be autosomal recessive.
| Descriptor ID |
D018703
|
| MeSH Number(s) |
G05.285
|
| Concept/Terms |
Founder Effect- Founder Effect
- Effect, Founder
- Effects, Founder
- Founder Effects
|
Below are MeSH descriptors whose meaning is more general than "Founder Effect".
Below are MeSH descriptors whose meaning is more specific than "Founder Effect".
This graph shows the total number of publications written about "Founder Effect" by people in this website by year, and whether "Founder Effect" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2017 | 3 | 2 | 5 |
| 2018 | 4 | 3 | 7 |
| 2020 | 0 | 2 | 2 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Founder Effect" by people in Profiles.
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SARS-CoV-2 variant evolution in the United States: High accumulation of viral mutations over time likely through serial Founder Events and mutational bursts. PLoS One. 2021; 16(7):e0255169.
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SARS-CoV-2 spike D614G change enhances replication and transmission. Nature. 2021 04; 592(7852):122-127.
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A Founder Effect Led Early SARS-CoV-2 Transmission in Spain. J Virol. 2021 01 13; 95(3).
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Phylogeography of SARS-CoV-2 pandemic in Spain: a story of multiple introductions, micro-geographic stratification, founder effects, and super-spreaders. Zool Res. 2020 Nov 18; 41(6):605-620.
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Six months of coronavirus: the mysteries scientists are still racing to solve. Nature. 2020 07; 583(7815):178-179.
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A CARD9 Founder Mutation Disrupts NF-?B Signaling by Inhibiting BCL10 and MALT1 Recruitment and Signalosome Formation. Front Immunol. 2018; 9:2366.
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Incomplete penetrance for isolated congenital asplenia in humans with mutations in translated and untranslated RPSA exons. Proc Natl Acad Sci U S A. 2018 08 21; 115(34):E8007-E8016.
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A founder nonsense variant in NUDT2 causes a recessive neurodevelopmental disorder in Saudi Arab children. Clin Genet. 2018 10; 94(3-4):393-395.
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Synergistic effect of TRAIL and irradiation in elimination of glioblastoma stem-like cells. Clin Exp Med. 2018 Aug; 18(3):399-411.
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A new case of limb girdle muscular dystrophy 2G in a Greek patient, founder effect and review of the literature. Neuromuscul Disord. 2018 06; 28(6):532-537.