Nod2 Signaling Adaptor Protein
"Nod2 Signaling Adaptor Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A NOD signaling adaptor protein that contains two C-terminal leucine-rich domains which recognize bacterial PEPTIDOGLYCAN. It signals via an N-terminal capase recruitment domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE KINASES. The protein plays a role in the host defense response by signaling the activation of CASPASES and the MAP KINASE SIGNALING SYSTEM. Mutations of the gene encoding the nucleotide oligomerization domain 2 protein have been associated with increased susceptibility to CROHN DISEASE.
| Descriptor ID |
D053473
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| MeSH Number(s) |
D12.644.360.024.131.500 D12.644.360.024.313.500 D12.644.360.075.358.500 D12.644.360.539.500.500 D12.776.157.057.006.500 D12.776.157.057.078.500 D12.776.476.024.139.500 D12.776.476.024.391.500 D12.776.476.075.358.500
|
| Concept/Terms |
Nod2 Signaling Adaptor Protein- Nod2 Signaling Adaptor Protein
- CARD15 Protein
- Nucleotide Oligomerization Domain 2 Protein
- Caspase Recruitment Domain Protein 15
|
Below are MeSH descriptors whose meaning is more general than "Nod2 Signaling Adaptor Protein".
Below are MeSH descriptors whose meaning is more specific than "Nod2 Signaling Adaptor Protein".
This graph shows the total number of publications written about "Nod2 Signaling Adaptor Protein" by people in this website by year, and whether "Nod2 Signaling Adaptor Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2017 | 5 | 1 | 6 |
| 2018 | 3 | 0 | 3 |
| 2019 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Nod2 Signaling Adaptor Protein" by people in Profiles.
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Palmitoylation of SARS-CoV-2 S protein is essential for viral infectivity. Signal Transduct Target Ther. 2021 06 11; 6(1):231.
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Lessons from Bacillus Calmette-Guérin: Harnessing Trained Immunity for Vaccine Development. Cells. 2020 09 16; 9(9).
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Tobacco, but Not Nicotine and Flavor-Less Electronic Cigarettes, Induces ACE2 and Immune Dysregulation. Int J Mol Sci. 2020 Jul 31; 21(15).
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Human ß-defensin 2 is involved in CCR2-mediated Nod2 signal transduction, leading to activation of the innate immune response in macrophages. Immunobiology. 2019 07; 224(4):502-510.
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Antibody neutralization of microbiota-derived circulating peptidoglycan dampens inflammation and ameliorates autoimmunity. Nat Microbiol. 2019 05; 4(5):766-773.
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Whole Exome Sequencing of HIV-1 long-term non-progressors identifies rare variants in genes encoding innate immune sensors and signaling molecules. Sci Rep. 2018 10 15; 8(1):15253.
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The NOD1 and NOD2 in mandarinfish (Siniperca chuatsi): molecular characterization, tissue distribution, and expression analysis. BMC Genet. 2018 08 17; 19(1):61.
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Genetic deficiency of NOD2 confers resistance to invasive aspergillosis. Nat Commun. 2018 07 06; 9(1):2636.
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Nod2 is required for the early innate immune clearance of Acinetobacter baumannii from the lungs. Sci Rep. 2017 12 12; 7(1):17429.
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The NOD2 receptor is crucial for immune responses towards New World Leishmania species. Sci Rep. 2017 11 09; 7(1):15219.