"TYK2 Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A Janus kinase subtype that is involved in signaling from a broad variety of CYTOKINE RECEPTORS. The TYK2 kinase is considered the founding member of the janus kinase family and was initially discovered as a signaling partner for the INTERFERON ALPHA-BETA RECEPTOR. The kinase has since been shown to signal from several INTERLEUKIN RECEPTORS.
| Descriptor ID |
D053634
|
| MeSH Number(s) |
D08.811.913.696.620.682.725.124.650 D12.776.476.393.650
|
| Concept/Terms |
TYK2 Kinase- TYK2 Kinase
- Kinase, TYK2
- Non-Receptor Tyrosine-Protein Kinase TYK2
- Non Receptor Tyrosine Protein Kinase TYK2
- Tyrosine Kinase 2
|
Below are MeSH descriptors whose meaning is more general than "TYK2 Kinase".
Below are MeSH descriptors whose meaning is more specific than "TYK2 Kinase".
This graph shows the total number of publications written about "TYK2 Kinase" by people in this website by year, and whether "TYK2 Kinase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 1 | 3 | 4 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 2 | 2 |
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Below are the most recent publications written about "TYK2 Kinase" by people in Profiles.
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SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway. J Virol. 2021 09 09; 95(19):e0086221.
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Update on human genetic susceptibility to COVID-19: susceptibility to virus and response. Hum Genomics. 2021 08 25; 15(1):57.
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SARS-CoV-2 Nonstructural Protein 1 Inhibits the Interferon Response by Causing Depletion of Key Host Signaling Factors. J Virol. 2021 06 10; 95(13):e0026621.
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Janus kinase signaling as risk factor and therapeutic target for severe SARS-CoV-2 infection. Eur J Immunol. 2021 05; 51(5):1071-1075.
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Potent and Selective Knockdown of Tyrosine Kinase 2 by Antisense Oligonucleotides. Immunohorizons. 2021 02 04; 5(2):70-80.
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Genetic mechanisms of critical illness in COVID-19. Nature. 2021 03; 591(7848):92-98.
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Exome-wide association study reveals novel psoriasis susceptibility locus at TNFSF15 and rare protective alleles in genes contributing to type I IFN signalling. Hum Mol Genet. 2017 11 01; 26(21):4301-4313.
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?he genetics of juvenile idiopathic arthritis: Searching for new susceptibility loci. Mol Med Rep. 2017 Dec; 16(6):8793-8798.
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Tyk2 as a target for immune regulation in human viral/bacterial pneumonia. Eur Respir J. 2017 07; 50(1).
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Hepatitis B Virus e Antigen Activates the Suppressor of Cytokine Signaling 2 to Repress Interferon Action. Sci Rep. 2017 05 11; 7(1):1729.