"Granzymes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of serine endopeptidases found in the SECRETORY GRANULES of LEUKOCYTES such as CYTOTOXIC T-LYMPHOCYTES and NATURAL KILLER CELLS. When secreted into the intercellular space granzymes act to eliminate transformed and virus-infected host cells.
| Descriptor ID |
D053804
|
| MeSH Number(s) |
D08.811.277.656.300.760.397 D08.811.277.656.959.350.397
|
| Concept/Terms |
Granzyme K- Granzyme K
- Natural Killer Cell Granule Tryptase-2
- Natural Killer Cell Granule Tryptase 2
- NK-Tryptase-2
- NK Tryptase 2
- Granzyme-3
- Granzyme 3
Granzyme A- Granzyme A
- Cytotoxic T-Lymphocyte Proteinase 1
- Cytotoxic T Lymphocyte Proteinase 1
- Hanukah Factor
Granzyme B- Granzyme B
- Fragmentin 2
- Cytotoxic T-Lymphocyte Associated 1 Protein
- Cytotoxic T Lymphocyte Associated 1 Protein
- Granzyme-Like Protein III
- Granzyme Like Protein III
- Cytotoxic Serine Protease B
|
Below are MeSH descriptors whose meaning is more general than "Granzymes".
Below are MeSH descriptors whose meaning is more specific than "Granzymes".
This graph shows the total number of publications written about "Granzymes" by people in this website by year, and whether "Granzymes" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 7 | 7 | 14 |
| 2018 | 1 | 6 | 7 |
| 2019 | 0 | 2 | 2 |
| 2020 | 0 | 3 | 3 |
| 2021 | 0 | 3 | 3 |
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Below are the most recent publications written about "Granzymes" by people in Profiles.
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In vitro Interleukin-7 treatment partially rescues MAIT cell dysfunction caused by SARS-CoV-2 infection. Sci Rep. 2021 07 08; 11(1):14090.
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Broad phenotypic alterations and potential dysfunction of lymphocytes in individuals clinically recovered from COVID-19. J Mol Cell Biol. 2021 07 06; 13(3):197-209.
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Circulating CD4 T Cells Elicited by Endemic Coronaviruses Display Vast Disparities in Abundance and Functional Potential Linked to Antigen Specificity and Age. J Infect Dis. 2021 05 20; 223(9):1555-1563.
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Immunological and inflammatory profiles during acute and convalescent phases of severe/ critically ill COVID-19 patients. Int Immunopharmacol. 2021 Aug; 97:107685.
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Interrogation of the cellular immunome of cancer patients with regard to the COVID-19 pandemic. J Immunother Cancer. 2021 03; 9(3).
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Mucosal-Associated Invariant T (MAIT) Cells Are Highly Activated and Functionally Impaired in COVID-19 Patients. Viruses. 2021 02 03; 13(2).
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Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent. J Clin Invest. 2020 09 01; 130(9):4694-4703.
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Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73- Phenotype Identifies Polyfunctional Cytotoxic Lymphocytes. Cells. 2020 07 22; 9(8).
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COVID-19 pneumonia: CD8+ T and NK cells are decreased in number but compensatory increased in cytotoxic potential. Clin Immunol. 2020 09; 218:108516.
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Aberrant hyperactivation of cytotoxic T-cell as a potential determinant of COVID-19 severity. Int J Infect Dis. 2020 Aug; 97:313-321.