"Caspases, Initiator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subtype of caspases that contain long pro-domain regions that regulate the activation of the enzyme. The pro-domain regions contain protein-protein interaction motifs that can interact with specific signaling adaptor proteins such as DEATH DOMAIN RECEPTORS; DED SIGNALING ADAPTOR PROTEINS; and CARD SIGNALING ADAPTOR PROTEINS. Once activated, the initiator caspases can activate other caspases such as the EFFECTOR CASPASES.
Descriptor ID |
D053471
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MeSH Number(s) |
D08.811.277.656.262.500.126.550 D08.811.277.656.300.200.126.550 D12.644.360.075.405.550 D12.776.476.075.405.550
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Caspases, Initiator".
Below are MeSH descriptors whose meaning is more specific than "Caspases, Initiator".
This graph shows the total number of publications written about "Caspases, Initiator" by people in this website by year, and whether "Caspases, Initiator" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2017 | 1 | 1 | 2 |
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Below are the most recent publications written about "Caspases, Initiator" by people in Profiles.
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Evolutionary loss of inflammasomes in the Carnivora and implications for the carriage of zoonotic infections. Cell Rep. 2021 08 24; 36(8):109614.
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Caspase1/11 signaling affects muscle regeneration and recovery following ischemia, and can be modulated by chloroquine. Mol Med. 2020 07 08; 26(1):69.
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Involvement of caspase-4 in IL-1 beta production and pyroptosis in human macrophages during dengue virus infection. Immunobiology. 2018 Apr - May; 223(4-5):356-364.
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Role of the inflammasome-related cytokines Il-1 and Il-18 during infection with murine coronavirus. J Neurovirol. 2017 Dec; 23(6):845-854.
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Equine coronavirus induces apoptosis in cultured cells. Vet Microbiol. 2008 Jun 22; 129(3-4):390-5.