"Withanolides" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Ergostane derivatives of 28 carbons with oxygens at C1, C22, and C26 positions and the side chain cyclized. They are found in WITHANIA plant genus and have cytotoxic and other effects.
| Descriptor ID |
D054358
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| MeSH Number(s) |
D04.210.500.247.222.537.888 D04.210.500.247.808.756.904 D10.570.938.795.904 D23.704.500.904
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Withanolides".
Below are MeSH descriptors whose meaning is more specific than "Withanolides".
This graph shows the total number of publications written about "Withanolides" by people in this website by year, and whether "Withanolides" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 1 | 0 | 1 |
| 2021 | 3 | 0 | 3 |
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Below are the most recent publications written about "Withanolides" by people in Profiles.
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Molecular mechanism of anti-SARS-CoV2 activity of Ashwagandha-derived withanolides. Int J Biol Macromol. 2021 Aug 01; 184:297-312.
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Withanone Ameliorates Stress Symptoms in Caenorhabditis Elegans by Acting through Serotonin Receptors. Pharmacopsychiatry. 2021 Sep; 54(5):215-223.
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Withanone from Withania somnifera Attenuates SARS-CoV-2 RBD and Host ACE2 Interactions to Rescue Spike Protein Induced Pathologies in Humanized Zebrafish Model. Drug Des Devel Ther. 2021; 15:1111-1133.
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Structure-activity relationship (SAR) and molecular dynamics study of withaferin-A fragment derivatives as potential therapeutic lead against main protease (Mpro) of SARS-CoV-2. J Mol Model. 2021 Feb 28; 27(3):97.
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Induction of stress resistance and extension of lifespan in Chaenorhabditis elegans serotonin-receptor knockout strains by withanolide A. Phytomedicine. 2021 Apr; 84:153482.
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Withaferin A: a potential therapeutic agent against COVID-19 infection. J Ovarian Res. 2020 Jul 19; 13(1):79.
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Withanone and Withaferin-A are predicted to interact with transmembrane protease serine 2 (TMPRSS2) and block entry of SARS-CoV-2 into cells. J Biomol Struct Dyn. 2022 01; 40(1):1-13.
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Withanone and caffeic acid phenethyl ester are predicted to interact with main protease (Mpro) of SARS-CoV-2 and inhibit its activity. J Biomol Struct Dyn. 2021 07; 39(11):3842-3854.
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Molecular docking, QSAR and ADMET studies of withanolide analogs against breast cancer. Drug Des Devel Ther. 2017; 11:1859-1870.