"Polyadenylation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The addition of a tail of polyadenylic acid (POLY A) to the 3' end of mRNA (RNA, MESSENGER). Polyadenylation involves recognizing the processing site signal, (AAUAAA), and cleaving of the mRNA to create a 3' OH terminal end to which poly A polymerase (POLYNUCLEOTIDE ADENYLYLTRANSFERASE) adds 60-200 adenylate residues. The 3' end processing of some messenger RNAs, such as histone mRNA, is carried out by a different process that does not include the addition of poly A as described here.
| Descriptor ID |
D026723
|
| MeSH Number(s) |
G02.111.760.225.710 G03.839.225.710 G05.308.700.225.710
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Polyadenylation".
Below are MeSH descriptors whose meaning is more specific than "Polyadenylation".
This graph shows the total number of publications written about "Polyadenylation" by people in this website by year, and whether "Polyadenylation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 1 | 0 | 1 |
| 2017 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Polyadenylation" by people in Profiles.
-
SARS-CoV-2 vaccine ChAdOx1 nCoV-19 infection of human cell lines reveals low levels of viral backbone gene transcription alongside very high levels of SARS-CoV-2 S glycoprotein gene transcription. Genome Med. 2021 03 15; 13(1):43.
-
The interface between coronaviruses and host cell RNA biology: Novel potential insights for future therapeutic intervention. Wiley Interdiscip Rev RNA. 2020 09; 11(5):e1614.
-
CFIm25 and alternative polyadenylation: Conflicting roles in cancer. Cancer Lett. 2019 09 10; 459:112-121.
-
Alternative Polyadenylation: Methods, Findings, and Impacts. Genomics Proteomics Bioinformatics. 2017 10; 15(5):287-300.
-
Distinct regulation of alternative polyadenylation and gene expression by nuclear poly(A) polymerases. Nucleic Acids Res. 2017 Sep 06; 45(15):8930-8942.
-
Characterization of the Role of Hexamer AGUAAA and Poly(A) Tail in Coronavirus Polyadenylation. PLoS One. 2016; 11(10):e0165077.
-
Regulation of coronaviral poly(A) tail length during infection. PLoS One. 2013; 8(7):e70548.
-
MicroRNA-mediated up-regulation of an alternatively polyadenylated variant of the mouse cytoplasmic {beta}-actin gene. Nucleic Acids Res. 2008 Nov; 36(19):6318-32.