Immunoglobulin Variable Region
"Immunoglobulin Variable Region" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions.
| Descriptor ID |
D007135
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| MeSH Number(s) |
D12.644.541.500.650.500 D12.776.124.486.485.680.650.500 D12.776.124.486.485.797 D12.776.124.790.651.680.650.500 D12.776.124.790.651.797 D12.776.377.715.548.680.650.500 D12.776.377.715.548.797 G02.111.570.060.425
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| Concept/Terms |
Immunoglobulin Variable Region- Immunoglobulin Variable Region
- Immunoglobulin Variable Regions
- Regions, Immunoglobulin Variable
- Variable Regions, Immunoglobulin
- Ig Variable Region
- Variable Region, Ig
- Ig Variable Regions
- Variable Regions, Ig
- Variable Region, Immunoglobulin
- Immunoglobulin V
Immunoglobulin Fv Fragments- Immunoglobulin Fv Fragments
- Fragment, Immunoglobulin Fv
- Fragments, Immunoglobulin Fv
- Fv Fragment, Immunoglobulin
- Fv Fragments, Immunoglobulin
- Immunoglobulin Fv Fragment
- Fv Antibody Fragments
- Antibody Fragment, Fv
- Antibody Fragments, Fv
- Fragment, Fv Antibody
- Fragments, Fv Antibody
- Fv Antibody Fragment
- Fv Fragments
- Fragment, Fv
- Fragments, Fv
- Fv Fragment
Framework Region, Immunoglobulin- Framework Region, Immunoglobulin
- Framework Regions, Immunoglobulin
- Immunoglobulin Framework Regions
- Ig Framework Region
- Framework Region, Ig
- Framework Regions, Ig
- Ig Framework Regions
- Immunoglobulin Framework Region
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Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Variable Region".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Variable Region".
This graph shows the total number of publications written about "Immunoglobulin Variable Region" by people in this website by year, and whether "Immunoglobulin Variable Region" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 2 | 2 |
| 2001 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 3 | 1 | 4 |
| 2018 | 1 | 3 | 4 |
| 2020 | 1 | 2 | 3 |
| 2021 | 2 | 2 | 4 |
To return to the timeline, click here.
Below are the most recent publications written about "Immunoglobulin Variable Region" by people in Profiles.
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Protocol for constructing large size human antibody heavy chain variable domain (VH) library and selection of SARS-CoV-2 neutralizing antibody domains. STAR Protoc. 2021 09 17; 2(3):100617.
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IgV somatic mutation of human anti-SARS-CoV-2 monoclonal antibodies governs neutralization and breadth of reactivity. JCI Insight. 2021 05 10; 6(9).
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Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes. Science. 2021 06 04; 372(6546):1108-1112.
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B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV. Cell. 2021 06 10; 184(12):3205-3221.e24.
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Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class. Cell Rep. 2021 04 06; 35(1):108950.
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A rapid novel strategy for screening of antibody phage libraries for production, purification, and functional characterization of amber stop codons containing single-chain antibody fragments. Biotechnol Prog. 2021 05; 37(3):e3136.
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Stereotypic neutralizing VH antibodies against SARS-CoV-2 spike protein receptor binding domain in patients with COVID-19 and healthy individuals. Sci Transl Med. 2021 01 27; 13(578).
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High Potency of a Bivalent Human VH Domain in SARS-CoV-2 Animal Models. Cell. 2020 10 15; 183(2):429-441.e16.
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Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients. Cell. 2020 08 20; 182(4):843-854.e12.
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Identification of Human Single-Domain Antibodies against SARS-CoV-2. Cell Host Microbe. 2020 06 10; 27(6):891-898.e5.