1-Alkyl-2-acetylglycerophosphocholine Esterase
"1-Alkyl-2-acetylglycerophosphocholine Esterase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A lipoprotein-associated PHOSPHOLIPASE A2 which modulates the action of PLATELET ACTIVATING FACTOR by hydrolyzing the SN-2 ester bond to yield the biologically inactive lyso-platelet-activating factor. It has specificity for phospholipid substrates with short-chain residues at the SN-2 position, but inactive against long-chain phospholipids. Deficiency in this enzyme is associated with many diseases including ASTHMA, and HYPERCHOLESTEROLEMIA.
Descriptor ID |
D043203
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MeSH Number(s) |
D08.811.277.352.100.680.750.937.249
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Concept/Terms |
1-Alkyl-2-acetylglycerophosphocholine Esterase- 1-Alkyl-2-acetylglycerophosphocholine Esterase
- 1 Alkyl 2 acetylglycerophosphocholine Esterase
- Esterase, 1-Alkyl-2-acetylglycerophosphocholine
- PAF Acetylhydrolase II
- Acetylhydrolase II, PAF
- Platelet-Activating Factor Hydrolase
- Factor Hydrolase, Platelet-Activating
- Hydrolase, Platelet-Activating Factor
- Platelet Activating Factor Hydrolase
- PAF 2-Acylhydrolase
- PAF 2 Acylhydrolase
- Lipoprotein-Associated Phospholipase A2
- Lipoprotein Associated Phospholipase A2
- Phospholipase A2, Lipoprotein-Associated
- Lp-PLA(2)
- Lp-PLA2
- Lp PLA2
- PAF 2-Acetylhydrolase
- 2-Acetylhydrolase, PAF
- PAF 2 Acetylhydrolase
- PAF Acetylhydrolase
- Acetylhydrolase, PAF
- Lipoprotein-Associated Phospholipase A(2)
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Below are MeSH descriptors whose meaning is more general than "1-Alkyl-2-acetylglycerophosphocholine Esterase".
Below are MeSH descriptors whose meaning is more specific than "1-Alkyl-2-acetylglycerophosphocholine Esterase".
This graph shows the total number of publications written about "1-Alkyl-2-acetylglycerophosphocholine Esterase" by people in this website by year, and whether "1-Alkyl-2-acetylglycerophosphocholine Esterase" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2007 | 1 | 0 | 1 |
2011 | 1 | 0 | 1 |
2017 | 3 | 1 | 4 |
2018 | 3 | 0 | 3 |
2019 | 0 | 1 | 1 |
2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "1-Alkyl-2-acetylglycerophosphocholine Esterase" by people in Profiles.
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Abnormal upregulation of cardiovascular disease biomarker PLA2G7 induced by proinflammatory macrophages in COVID-19 patients. Sci Rep. 2021 03 24; 11(1):6811.
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Lipid Profiles in Lyme Borreliosis: A Potential Role for Apheresis? Horm Metab Res. 2019 May; 51(5):326-329.
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Distribution of Paraoxonase-1 (PON-1) and Lipoprotein Phospholipase A2 (Lp-PLA2) across Lipoprotein Subclasses in Subjects with Type 2 Diabetes. Oxid Med Cell Longev. 2018; 2018:1752940.
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Differential expression of Lp-PLA2 in obesity and type 2 diabetes and the influence of lipids. Diabetologia. 2018 05; 61(5):1155-1166.
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Usefulness of Lipoprotein-Associated Phospholipase A2 Activity and C-Reactive Protein in Identifying High-Risk Smokers for Atherosclerotic Cardiovascular Disease (from the Atherosclerosis Risk in Communities Study). Am J Cardiol. 2018 05 01; 121(9):1056-1064.
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Elevated serum levels of lipoprotein-associated phospholipase A2 predict mortality rates in patients with sepsis. Mol Med Rep. 2018 Jan; 17(1):1791-1798.
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Lipoprotein-associated phospholipase A2 and its relationship with markers of subclinical cardiovascular disease: A systematic review. J Clin Lipidol. 2017 Mar - Apr; 11(2):328-337.
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Endothelial Dysfunction in Children With Obstructive Sleep Apnea Is Associated With Elevated Lipoprotein-Associated Phospholipase A2 Plasma Activity Levels. J Am Heart Assoc. 2017 02 09; 6(2).
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Oxidative stress and frailty: A systematic review and synthesis of the best evidence. Maturitas. 2017 May; 99:66-72.
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Effects of the Ala379Val polymorphism of lipoprotein-associated phospholipase A2 on thrombosis and inflammation in hypertensive patients. Int J Cardiol. 2011 Oct 20; 152(2):247-9.