"RNA, Small Interfering" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
| Descriptor ID |
D034741
|
| MeSH Number(s) |
D13.150.650.700 D13.444.735.150.700 D13.444.735.790.552.875
|
| Concept/Terms |
RNA, Small Interfering- RNA, Small Interfering
- Interfering RNA, Small
- Short Interfering RNA
- Interfering RNA, Short
- RNA, Short Interfering
- Small Interfering RNA
- siRNA
Piwi-Interacting RNA- Piwi-Interacting RNA
- Piwi Interacting RNA
- RNA, Piwi-Interacting
- RNA, Piwi Interacting
- piRNA
Short Hairpin RNA- Short Hairpin RNA
- Hairpin RNA, Short
- RNA, Short Hairpin
- Small Hairpin RNA
- Hairpin RNA, Small
- RNA, Small Hairpin
- shRNA
Repeat-Associated siRNA- Repeat-Associated siRNA
- Repeat Associated siRNA
- siRNA, Repeat-Associated
- siRNA, Repeat Associated
Scan RNA- Scan RNA
- scnRNA
- Small Scan RNA
- RNA, Small Scan
- Scan RNA, Small
- RNA, Scan
Trans-Acting siRNA- Trans-Acting siRNA
- Trans Acting siRNA
- tasiRNA
- siRNA, Trans-Acting
- siRNA, Trans Acting
|
Below are MeSH descriptors whose meaning is more general than "RNA, Small Interfering".
Below are MeSH descriptors whose meaning is more specific than "RNA, Small Interfering".
This graph shows the total number of publications written about "RNA, Small Interfering" by people in this website by year, and whether "RNA, Small Interfering" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 1 | 2 |
| 2004 | 3 | 1 | 4 |
| 2005 | 2 | 2 | 4 |
| 2006 | 3 | 2 | 5 |
| 2007 | 1 | 2 | 3 |
| 2008 | 0 | 4 | 4 |
| 2009 | 3 | 3 | 6 |
| 2010 | 2 | 8 | 10 |
| 2011 | 2 | 2 | 4 |
| 2012 | 0 | 4 | 4 |
| 2013 | 0 | 5 | 5 |
| 2014 | 0 | 3 | 3 |
| 2015 | 3 | 5 | 8 |
| 2016 | 0 | 4 | 4 |
| 2017 | 13 | 100 | 113 |
| 2018 | 21 | 65 | 86 |
| 2019 | 7 | 24 | 31 |
| 2020 | 2 | 8 | 10 |
| 2021 | 2 | 6 | 8 |
To return to the timeline, click here.
Below are the most recent publications written about "RNA, Small Interfering" by people in Profiles.
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Deliver the promise: RNAs as a new class of molecular entities for therapy and vaccination. Pharmacol Ther. 2022 02; 230:107967.
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SARS-CoV-2 infection induces the activation of tissue factor-mediated coagulation via activation of acid sphingomyelinase. Blood. 2021 07 29; 138(4):344-349.
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IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro. Nat Commun. 2021 07 28; 12(1):4584.
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An isoform of Dicer protects mammalian stem cells against multiple RNA viruses. Science. 2021 07 09; 373(6551):231-236.
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SARS-CoV-2 Entry: At the Crossroads of CD147 and ACE2. Cells. 2021 06 08; 10(6).
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Designing an effective therapeutic siRNA to silence RdRp gene of SARS-CoV-2. Infect Genet Evol. 2021 09; 93:104951.
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A SARS-CoV-2 targeted siRNA-nanoparticle therapy for COVID-19. Mol Ther. 2021 07 07; 29(7):2219-2226.
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DNA-inspired nanomaterials for enhanced endosomal escape. Proc Natl Acad Sci U S A. 2021 05 11; 118(19).
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Silencing of SARS-CoV-2 with modified siRNA-peptide dendrimer formulation. Allergy. 2021 09; 76(9):2840-2854.
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The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection. J Biol Chem. 2021 Jan-Jun; 296:100759.