"PPAR alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR GAMMA is important to metabolism of LIPIDS. It is the target of FIBRATES to control HYPERLIPIDEMIAS.
Descriptor ID |
D047493
|
MeSH Number(s) |
D12.776.826.239.500
|
Concept/Terms |
PPAR alpha- PPAR alpha
- Peroxisome Proliferator-Activated Receptor alpha
- Peroxisome Proliferator Activated Receptor alpha
- PPARalpha
|
Below are MeSH descriptors whose meaning is more general than "PPAR alpha".
Below are MeSH descriptors whose meaning is more specific than "PPAR alpha".
This graph shows the total number of publications written about "PPAR alpha" by people in this website by year, and whether "PPAR alpha" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2009 | 1 | 1 | 2 |
2010 | 1 | 0 | 1 |
2016 | 1 | 0 | 1 |
2017 | 4 | 2 | 6 |
2018 | 3 | 2 | 5 |
2019 | 1 | 1 | 2 |
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Below are the most recent publications written about "PPAR alpha" by people in Profiles.
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N-acylethanolamine regulation of TLR3-induced hyperthermia and neuroinflammatory gene expression: A role for PPARa. J Neuroimmunol. 2021 09 15; 358:577654.
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Exercise as medicine for COVID-19: On PPAR with emerging pharmacotherapy. Med Hypotheses. 2020 Oct; 143:110197.
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Fenofibrate increases the amount of sulfatide which seems beneficial against Covid-19. Med Hypotheses. 2020 Oct; 143:110127.
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Polysaccharides derived from natural sources regulate triglyceride and cholesterol metabolism: a review of the mechanisms. Food Funct. 2019 May 22; 10(5):2330-2339.
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Hepatic PPARa is critical in the metabolic adaptation to sepsis. J Hepatol. 2019 05; 70(5):963-973.
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Impact of fibrates on circulating cystatin C levels: a systematic review and meta-analysis of clinical trials. Ann Med. 2018 09; 50(6):485-493.
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FGF21 mediates the protective effect of fenofibrate against acetaminophen -induced hepatotoxicity via activating autophagy in mice. Biochem Biophys Res Commun. 2018 09 05; 503(2):474-481.
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Work in Progress: Drugs in Development. Clin Liver Dis. 2018 08; 22(3):501-515.
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Glucagon-like peptide-1 ameliorates cardiac lipotoxicity in diabetic cardiomyopathy via the PPARa pathway. Aging Cell. 2018 08; 17(4):e12763.
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PPAR-a Agonist Improves Hyperglycemia-Induced Oxidative Stress in Pancreatic Cells by Potentiating Antioxidant Defense System. Drug Res (Stuttg). 2018 Jun; 68(6):355-360.