NAV1.5 Voltage-Gated Sodium Channel
"NAV1.5 Voltage-Gated Sodium Channel" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A voltage-gated sodium channel subtype that mediates the sodium ion PERMEABILITY of CARDIOMYOCYTES. Defects in the SCN5A gene, which codes for the alpha subunit of this sodium channel, are associated with a variety of CARDIAC DISEASES that result from loss of sodium channel function.
| Descriptor ID |
D062554
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| MeSH Number(s) |
D12.776.157.530.400.875.750.500 D12.776.543.550.450.875.750.500 D12.776.543.585.400.875.750.500 D12.776.631.960.500
|
| Concept/Terms |
NAV1.5 Voltage-Gated Sodium Channel- NAV1.5 Voltage-Gated Sodium Channel
- NAV1.5 Voltage Gated Sodium Channel
- Voltage-Gated Sodium Channel Type 5
- Voltage Gated Sodium Channel Type 5
- Type 5 Voltage-Gated Sodium Channel
- Type 5 Voltage Gated Sodium Channel
Voltage-Gated Sodium Channel Type 5 Subunit alpha- Voltage-Gated Sodium Channel Type 5 Subunit alpha
- Voltage Gated Sodium Channel Type 5 Subunit alpha
- SCN5A Sodium Channel alpha Subunit
- Voltage-Gated Na+ Channel Na(v)1.5a
- Sodium Channel Protein Type 5 Subunit alpha
- Sodium Channel, Voltage-Gated, Type V, alpha Subunit
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Below are MeSH descriptors whose meaning is more general than "NAV1.5 Voltage-Gated Sodium Channel".
Below are MeSH descriptors whose meaning is more specific than "NAV1.5 Voltage-Gated Sodium Channel".
This graph shows the total number of publications written about "NAV1.5 Voltage-Gated Sodium Channel" by people in this website by year, and whether "NAV1.5 Voltage-Gated Sodium Channel" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2017 | 4 | 2 | 6 |
| 2018 | 5 | 1 | 6 |
| 2019 | 1 | 1 | 2 |
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Below are the most recent publications written about "NAV1.5 Voltage-Gated Sodium Channel" by people in Profiles.
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The K219T-Lamin mutation induces conduction defects through epigenetic inhibition of SCN5A in human cardiac laminopathy. Nat Commun. 2019 05 22; 10(1):2267.
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Heterogeneity of the action potential duration is required for sustained atrial fibrillation. JCI Insight. 2019 04 25; 5.
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New risk stratification on SCN5A mutation in Brugada syndrome. Int J Cardiol. 2018 11 15; 271:123.
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Postmortem Analysis of 4 Mutation Hotspots of KCNQ1, KCNH2, and SCN5A Genes in Sudden Unexplained Death in Southwest of China. Am J Forensic Med Pathol. 2018 Sep; 39(3):218-222.
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SCN5A mutations in 442 neonates and children: genotype-phenotype correlation and identification of higher-risk subgroups. Eur Heart J. 2018 08 14; 39(31):2879-2887.
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Multifocal atrial and ventricular premature contractions with an increased risk of dilated cardiomyopathy caused by a Nav1.5 gain-of-function mutation (G213D). Int J Cardiol. 2018 04 15; 257:160-167.
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A common variant alters SCN5A-miR-24 interaction and associates with heart failure mortality. J Clin Invest. 2018 03 01; 128(3):1154-1163.
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Application of Multigene Panel Sequencing in Patients with Prolonged Rate-corrected QT Interval and No Pathogenic Variants Detected in KCNQ1, KCNH2, and SCN5A. Ann Lab Med. 2018 Jan; 38(1):54-58.
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Differential calcium sensitivity in NaV 1.5 mixed syndrome mutants. J Physiol. 2017 09 15; 595(18):6165-6186.
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Novel idiopathic DCM-related SCN5A variants localised in DI-S4 predispose electrical disorders by reducing peak sodium current density. J Med Genet. 2017 11; 54(11):762-770.