"Methotrexate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
| Descriptor ID |
D008727
|
| MeSH Number(s) |
D03.633.100.733.631.192.500
|
| Concept/Terms |
Methotrexate Sodium- Methotrexate Sodium
- Sodium, Methotrexate
- Methotrexate, Sodium Salt
- Methotrexate, Disodium Salt
|
Below are MeSH descriptors whose meaning is more general than "Methotrexate".
Below are MeSH descriptors whose meaning is more specific than "Methotrexate".
This graph shows the total number of publications written about "Methotrexate" by people in this website by year, and whether "Methotrexate" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 1 | 2 |
| 2008 | 0 | 1 | 1 |
| 2010 | 1 | 1 | 2 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 2 | 1 | 3 |
| 2016 | 0 | 2 | 2 |
| 2017 | 27 | 38 | 65 |
| 2018 | 22 | 32 | 54 |
| 2019 | 11 | 16 | 27 |
| 2020 | 6 | 4 | 10 |
| 2021 | 2 | 5 | 7 |
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Below are the most recent publications written about "Methotrexate" by people in Profiles.
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Repurposing Methotrexate in Dampening SARS-CoV2-S1-Mediated IL6 Expression: Lessons Learnt from Lung Cancer. Inflammation. 2022 Feb; 45(1):172-179.
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Relapse of microscopic polyangiitis after vaccination against COVID-19: A case report. J Med Virol. 2021 Dec; 93(12):6439-6441.
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A possible interaction between favipiravir and methotrexate: Drug-induced hepatotoxicity in a patient with osteosarcoma. J Oncol Pharm Pract. 2022 Mar; 28(2):445-448.
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A case of psoriasis successfully treated by extracorporeal photopheresis during COVID-19 pandemic. Transfus Apher Sci. 2021 Oct; 60(5):103200.
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Methotrexate and glucocorticoids, but not anticytokine therapy, impair the immunogenicity of a single dose of the BNT162b2 mRNA COVID-19 vaccine in patients with chronic inflammatory arthritis. Ann Rheum Dis. 2021 12; 80(12):1635-1638.
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Successful BNT162b2 booster vaccinations in a patient with rheumatoid arthritis and initially negative antibody response. Ann Rheum Dis. 2021 10; 80(10):1361-1362.
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[Does methotrexate influence the efficacy of vaccination against SARS-CoV-2?] Z Rheumatol. 2021 Aug; 80(6):552-554.
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Does methotrexate influence COVID-19 infection? Case series and mechanistic data. Arthritis Res Ther. 2021 06 10; 23(1):166.
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The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models. Virus Res. 2021 09; 302:198469.
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Efficacy and Safety of Methotrexate for the Treatment of Autoimmune Virus-Negative Myocarditis: A Case Series. J Clin Rheumatol. 2021 Jun 01; 27(4):e143-e146.