"tau Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Microtubule-associated proteins that are mainly expressed in neurons. Tau proteins constitute several isoforms and play an important role in the assembly of tubulin monomers into microtubules and in maintaining the cytoskeleton and axonal transport. Aggregation of specific sets of tau proteins in filamentous inclusions is the common feature of intraneuronal and glial fibrillar lesions (NEUROFIBRILLARY TANGLES; NEUROPIL THREADS) in numerous neurodegenerative disorders (ALZHEIMER DISEASE; TAUOPATHIES).
| Descriptor ID |
D016875
|
| MeSH Number(s) |
D12.776.220.600.450.510 D12.776.631.560.510
|
| Concept/Terms |
tau Proteins- tau Proteins
- Proteins, tau
- tau Protein
- Protein, tau
|
Below are MeSH descriptors whose meaning is more general than "tau Proteins".
Below are MeSH descriptors whose meaning is more specific than "tau Proteins".
This graph shows the total number of publications written about "tau Proteins" by people in this website by year, and whether "tau Proteins" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 2 | 0 | 2 |
| 2009 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 2 | 0 | 2 |
| 2017 | 13 | 10 | 23 |
| 2018 | 13 | 15 | 28 |
| 2019 | 5 | 7 | 12 |
| 2020 | 0 | 2 | 2 |
| 2021 | 2 | 1 | 3 |
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Below are the most recent publications written about "tau Proteins" by people in Profiles.
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Editorial: Targets for Disease-Modifying Therapies in Alzheimer's Disease, Including Amyloid ß and Tau Protein. Med Sci Monit. 2021 Jul 26; 27:e934077.
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Neurodegenerative proteinopathies associated with neuroinfections. J Neural Transm (Vienna). 2021 10; 128(10):1551-1566.
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Blood neurofilament light chain and total tau levels at admission predict death in COVID-19 patients. J Neurol. 2021 Dec; 268(12):4436-4442.
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SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration. Biochem Biophys Res Commun. 2021 05 21; 554:94-98.
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Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations. Cells. 2021 02 13; 10(2).
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COVID-19 lessons from the dish: Dissecting CNS manifestations through brain organoids. EMBO J. 2021 01 15; 40(2):e107213.
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SARS-CoV-2 targets neurons of 3D human brain organoids. EMBO J. 2020 10 15; 39(20):e106230.
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Acute necrotizing encephalopathy with SARS-CoV-2 RNA confirmed in cerebrospinal fluid. Neurology. 2020 09 08; 95(10):445-449.
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Evaluation of pyrazolopyrimidine derivatives as microtubule affinity regulating kinase 4 inhibitors: Towards therapeutic management of Alzheimer's disease. J Biomol Struct Dyn. 2020 Aug; 38(13):3892-3907.
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Characterisation of serum total tau following paediatric traumatic brain injury: a case-control study. Lancet Child Adolesc Health. 2019 08; 3(8):558-567.