Oxidoreductases Acting on CH-CH Group Donors
"Oxidoreductases Acting on CH-CH Group Donors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subclass of enzymes which includes all dehydrogenases acting on carbon-carbon bonds. This enzyme group includes all the enzymes that introduce double bonds into substrates by direct dehydrogenation of carbon-carbon single bonds.
| Descriptor ID |
D044925
|
| MeSH Number(s) |
D08.811.682.660
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Oxidoreductases Acting on CH-CH Group Donors".
Below are MeSH descriptors whose meaning is more specific than "Oxidoreductases Acting on CH-CH Group Donors".
This graph shows the total number of publications written about "Oxidoreductases Acting on CH-CH Group Donors" by people in this website by year, and whether "Oxidoreductases Acting on CH-CH Group Donors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 2 | 1 | 3 |
| 2018 | 4 | 3 | 7 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 3 | 4 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Oxidoreductases Acting on CH-CH Group Donors" by people in Profiles.
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Efficacy and safety of dihydroorotate dehydrogenase (DHODH) inhibitors "leflunomide" and "teriflunomide" in Covid-19: A narrative review. Eur J Pharmacol. 2021 Sep 05; 906:174233.
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A comprehensive drug repurposing study for COVID19 treatment: novel putative dihydroorotate dehydrogenase inhibitors show association to serotonin-dopamine receptors. Brief Bioinform. 2021 03 22; 22(2):1023-1037.
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IMU-838, a Developmental DHODH Inhibitor in Phase II for Autoimmune Disease, Shows Anti-SARS-CoV-2 and Broad-Spectrum Antiviral Efficacy In Vitro. Viruses. 2020 12 05; 12(12).
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Interferon-stimulated gene products as regulators of central carbon metabolism. FEBS J. 2021 06; 288(12):3715-3726.
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The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines. Virus Res. 2021 01 15; 292:198246.
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Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase. Protein Cell. 2020 10; 11(10):699-702.
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Dihydroorotate dehydrogenase inhibitors in SARS-CoV-2 infection. Eur J Clin Invest. 2020 Oct; 50(10):e13366.
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Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2. Protein Cell. 2020 10; 11(10):723-739.
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Discovery, Optimization, and Target Identification of Novel Potent Broad-Spectrum Antiviral Inhibitors. J Med Chem. 2019 04 25; 62(8):4056-4073.
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Negative effect of vitamin D on kidney function: a Mendelian randomization study. Nephrol Dial Transplant. 2018 12 01; 33(12):2139-2145.