"Frameshifting, Ribosomal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A directed change in translational READING FRAMES that allows the production of a single protein from two or more OVERLAPPING GENES. The process is programmed by the nucleotide sequence of the MRNA and is sometimes also affected by the secondary or tertiary mRNA structure. It has been described mainly in VIRUSES (especially RETROVIRUSES); RETROTRANSPOSONS; and bacterial insertion elements but also in some cellular genes.
| Descriptor ID |
D018965
|
| MeSH Number(s) |
G02.111.660.871.200 G03.734.871.200 G05.308.215
|
| Concept/Terms |
Frameshifting, Ribosomal- Frameshifting, Ribosomal
- Ribosomal Frame Shift
- Frame Shift, Ribosomal
- Frame Shifts, Ribosomal
- Ribosomal Frame Shifts
- Frameshifting, Translational
- Translational Frameshifting
- Ribosomal Frameshifting
- Ribosomal Frameshift
- Frameshift, Ribosomal
- Frameshifts, Ribosomal
- Ribosomal Frameshifts
- Ribosomal Frame Shifting
- Frame Shifting, Ribosomal
|
Below are MeSH descriptors whose meaning is more general than "Frameshifting, Ribosomal".
Below are MeSH descriptors whose meaning is more specific than "Frameshifting, Ribosomal".
This graph shows the total number of publications written about "Frameshifting, Ribosomal" by people in this website by year, and whether "Frameshifting, Ribosomal" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 2 | 2 |
| 2006 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2020 | 1 | 1 | 2 |
| 2021 | 3 | 0 | 3 |
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Below are the most recent publications written about "Frameshifting, Ribosomal" by people in Profiles.
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A Novel Frameshifting Inhibitor Having Antiviral Activity against Zoonotic Coronaviruses. Viruses. 2021 08 18; 13(8).
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Targeting Ribosomal Frameshifting as an Antiviral Strategy: From HIV-1 to SARS-CoV-2. Acc Chem Res. 2021 09 07; 54(17):3349-3361.
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Antiviral strategies targeting host factors and mechanisms obliging +ssRNA viral pathogens. Bioorg Med Chem. 2021 09 15; 46:116356.
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Structural dynamics of single SARS-CoV-2 pseudoknot molecules reveal topologically distinct conformers. Nat Commun. 2021 08 06; 12(1):4749.
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The SARS-CoV-2 Programmed -1 Ribosomal Frameshifting Element Crystal Structure Solved to 2.09 Å Using Chaperone-Assisted RNA Crystallography. ACS Chem Biol. 2021 08 20; 16(8):1469-1481.
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Restriction of SARS-CoV-2 replication by targeting programmed -1 ribosomal frameshifting. Proc Natl Acad Sci U S A. 2021 06 29; 118(26).
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From Recoding to Peptides for MHC Class I Immune Display: Enriching Viral Expression, Virus Vulnerability and Virus Evasion. Viruses. 2021 06 27; 13(7).
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Modulation of Viral Programmed Ribosomal Frameshifting and Stop Codon Readthrough by the Host Restriction Factor Shiftless. Viruses. 2021 06 25; 13(7).
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Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome. Science. 2021 06 18; 372(6548):1306-1313.
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De novo 3D models of SARS-CoV-2 RNA elements from consensus experimental secondary structures. Nucleic Acids Res. 2021 04 06; 49(6):3092-3108.