Interleukin-1 Receptor-Associated Kinases
"Interleukin-1 Receptor-Associated Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of intracellular signaling kinases that were identified by their ability to signal from the activated INTERLEUKIN-1 RECEPTORS. Signaling from these kinases involves their interaction with SIGNAL TRANSDUCING ADAPTOR PROTEINS such as MYELOID DIFFERENTIATION FACTOR 88 and TNF RECEPTOR-ASSOCIATED FACTOR 6.
| Descriptor ID |
D053592
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| MeSH Number(s) |
D08.811.913.696.620.682.700.526 D12.644.360.370 D12.776.476.384
|
| Concept/Terms |
Interleukin-1 Receptor-Associated Kinases- Interleukin-1 Receptor-Associated Kinases
- Interleukin 1 Receptor Associated Kinases
- Kinases, Interleukin-1 Receptor-Associated
- Receptor-Associated Kinases, Interleukin-1
- IRAK Kinases
- Kinases, IRAK
- IL-1 Receptor-Associated Kinase
- IL 1 Receptor Associated Kinase
- Kinase, IL-1 Receptor-Associated
- Receptor-Associated Kinase, IL-1
- Interleukin-1 Receptor-Associated Kinase
- Interleukin 1 Receptor Associated Kinase
- Kinase, Interleukin-1 Receptor-Associated
- Receptor-Associated Kinase, Interleukin-1
|
Below are MeSH descriptors whose meaning is more general than "Interleukin-1 Receptor-Associated Kinases".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-1 Receptor-Associated Kinases".
This graph shows the total number of publications written about "Interleukin-1 Receptor-Associated Kinases" by people in this website by year, and whether "Interleukin-1 Receptor-Associated Kinases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 7 | 5 | 12 |
| 2018 | 1 | 2 | 3 |
| 2019 | 2 | 0 | 2 |
| 2021 | 2 | 0 | 2 |
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Below are the most recent publications written about "Interleukin-1 Receptor-Associated Kinases" by people in Profiles.
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SARS-CoV-2/ACE2 Interaction Suppresses IRAK-M Expression and Promotes Pro-Inflammatory Cytokine Production in Macrophages. Front Immunol. 2021; 12:683800.
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Interleukin-1- Receptor Kinase 4 Inhibition: Achieving Immunomodulatory Synergy to Mitigate the Impact of COVID-19. Front Immunol. 2021; 12:693085.
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Involvement of Interleukin-1 Receptor-Associated Kinase 4 and Interferon Regulatory Factor 5 in the Immunopathogenesis of SARS-CoV-2 Infection: Implications for the Treatment of COVID-19. Front Immunol. 2021; 12:638446.
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SARS-CoV-2 induces human plasmacytoid predendritic cell diversification via UNC93B and IRAK4. J Exp Med. 2021 04 05; 218(4).
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Dendritic cell exosome-shuttled miRNA146a regulates exosome-induced endothelial cell inflammation by inhibiting IRAK-1: A feedback control mechanism. Mol Med Rep. 2019 Dec; 20(6):5315-5323.
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Interleukin-1ß-induced IRAK1 ubiquitination is required for TH-GM-CSF cell differentiation in T cell-mediated inflammation. J Autoimmun. 2019 08; 102:50-64.
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Mechanism of dysfunction of human variants of the IRAK4 kinase and a role for its kinase activity in interleukin-1 receptor signaling. J Biol Chem. 2018 09 28; 293(39):15208-15220.
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Expression of microRNAs and IRAK1 pathway genes are altered in gastric cancer patients with Helicobacter pylori infection. J Cell Biochem. 2018 09; 119(9):7570-7576.
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miR-146a-5p promotes replication of infectious bronchitis virus by targeting IRAK2 and TNFRSF18. Microb Pathog. 2018 Jul; 120:32-36.
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Evaluation of the TLR negative regulatory network in CVID patients. Genes Immun. 2019 03; 20(3):198-206.