"Complement C3a" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The smaller fragment generated from the cleavage of complement C3 by C3 CONVERTASE. C3a, a 77-amino acid peptide, is a mediator of local inflammatory process. It induces smooth MUSCLE CONTRACTION, and HISTAMINE RELEASE from MAST CELLS and LEUKOCYTES. C3a is considered an anaphylatoxin along with COMPLEMENT C4A; COMPLEMENT C5A; and COMPLEMENT C5A, DES-ARGININE.
| Descriptor ID |
D015926
|
| MeSH Number(s) |
D12.776.124.486.274.024.250 D12.776.124.486.274.250.250
|
| Concept/Terms |
Complement C3a- Complement C3a
- C3a, Complement
- Complement 3a
- Complement Component 3a
- Component 3a, Complement
- C3a Complement
- Complement, C3a
|
Below are MeSH descriptors whose meaning is more general than "Complement C3a".
Below are MeSH descriptors whose meaning is more specific than "Complement C3a".
This graph shows the total number of publications written about "Complement C3a" by people in this website by year, and whether "Complement C3a" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2021 | 2 | 1 | 3 |
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Below are the most recent publications written about "Complement C3a" by people in Profiles.
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Elevated Expression Levels of Lung Complement Anaphylatoxin, Neutrophil Chemoattractant Chemokine IL-8, and RANTES in MERS-CoV-Infected Patients: Predictive Biomarkers for Disease Severity and Mortality. J Clin Immunol. 2021 10; 41(7):1607-1620.
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SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation. Sci Immunol. 2021 04 07; 6(58).
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Complement Overactivation and Consumption Predicts In-Hospital Mortality in SARS-CoV-2 Infection. Front Immunol. 2021; 12:663187.
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Pharmacological approach for the reduction of inflammatory and prothrombotic hyperactive state in COVID-19 positive patients by acting on complement cascade. Hum Immunol. 2021 Apr; 82(4):264-269.
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COVID-19: A collision of complement, coagulation and inflammatory pathways. J Thromb Haemost. 2020 09; 18(9):2110-2117.
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The effect of hydroxychloroquine on haemostasis, complement, inflammation and angiogenesis in patients with antiphospholipid antibodies. Rheumatology (Oxford). 2018 01 01; 57(1):120-124.
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Complement activation products in acute heart failure: Potential role in pathophysiology, responses to treatment and impacts on long-term survival. Eur Heart J Acute Cardiovasc Care. 2018 Jun; 7(4):348-357.
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Human plasmacytoid dendritic cells express receptors for anaphylatoxins C3a and C5a and are chemoattracted to C3a and C5a. J Invest Dermatol. 2006 Nov; 126(11):2422-9.