"Leukotrienes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of biologically active compounds derived from arachidonic acid by oxidative metabolism through the 5-lipoxygenase pathway. They participate in host defense reactions and pathophysiological conditions such as immediate hypersensitivity and inflammation. They have potent actions on many essential organs and systems, including the cardiovascular, pulmonary, and central nervous system as well as the gastrointestinal tract and the immune system.
| Descriptor ID |
D015289
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| MeSH Number(s) |
D10.251.355.255.100.450 D10.251.355.310.166.887 D23.469.050.175.450
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Leukotrienes".
Below are MeSH descriptors whose meaning is more specific than "Leukotrienes".
This graph shows the total number of publications written about "Leukotrienes" by people in this website by year, and whether "Leukotrienes" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 2 | 2 |
| 2012 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 1 | 2 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 1 | 2 |
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Below are the most recent publications written about "Leukotrienes" by people in Profiles.
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Angioedema: differential diagnosis and acute management. Postgrad Med. 2021 Sep; 133(7):765-770.
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The role of 5-lipoxygenase in the pathophysiology of COVID-19 and its therapeutic implications. Inflamm Res. 2021 Aug; 70(8):877-889.
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Role of leukotriene pathway and montelukast in pulmonary and extrapulmonary manifestations of Covid-19: The enigmatic entity. Eur J Pharmacol. 2021 Aug 05; 904:174196.
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Deciphering the Molecular Details of the Lipoxin Formation Mechanism in the 5(S),15(S)-DiHpETE Biosynthetic Pathway Catalyzed by Reticulocyte 15-Lipoxygenase-1. J Phys Chem B. 2020 12 17; 124(50):11406-11418.
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Leukotrienes, a potential target for Covid-19. Prostaglandins Leukot Essent Fatty Acids. 2020 10; 161:102174.
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Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme. Antioxid Redox Signal. 2020 01 01; 32(1):1-17.
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Trauma and hemorrhagic shock activate molecular association of 5-lipoxygenase and 5-lipoxygenase-Activating protein in lung tissue. J Surg Res. 2018 09; 229:262-270.
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Neuropsychiatric Events Associated with Leukotriene-Modifying Agents: A Systematic Review. Drug Saf. 2018 03; 41(3):253-265.
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Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy. Antioxid Redox Signal. 2018 05 10; 28(14):1265-1285.
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Exhaled breath condensate pH and cysteinyl leukotriens in patients with chronic cough secondary to acid gastroesophageal reflux. J Breath Res. 2016 12 22; 11(1):016002.