"PDZ Domains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Protein interaction domains of about 70-90 amino acid residues, named after a common structure found in PSD-95, Discs Large, and Zona Occludens 1 proteins. PDZ domains are involved in the recruitment and interaction of proteins, and aid the formation of protein scaffolds and signaling networks. This is achieved by sequence-specific binding between a PDZ domain in one protein and a PDZ motif in another protein.
| Descriptor ID |
D054731
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| MeSH Number(s) |
G02.111.570.820.709.275.750.500.500
|
| Concept/Terms |
PDZ Domains- PDZ Domains
- Domain, PDZ
- Domains, PDZ
- PDZ Domain
- PDZ Interaction Domains
- Domain, PDZ Interaction
- Domains, PDZ Interaction
- Interaction Domain, PDZ
- Interaction Domains, PDZ
- PDZ Interaction Domain
- PSD95-DLG-ZO1 Domains
- Domain, PSD95-DLG-ZO1
- Domains, PSD95-DLG-ZO1
- PSD95 DLG ZO1 Domains
- PSD95-DLG-ZO1 Domain
- DLG Homology Repeats Domains
- GLGF Repeats Domains
- Domain, GLGF Repeats
- Domains, GLGF Repeats
- GLGF Repeats Domain
- Repeats Domain, GLGF
- Repeats Domains, GLGF
- DHR Domains
- DHR Domain
- Domain, DHR
- Domains, DHR
|
Below are MeSH descriptors whose meaning is more general than "PDZ Domains".
Below are MeSH descriptors whose meaning is more specific than "PDZ Domains".
This graph shows the total number of publications written about "PDZ Domains" by people in this website by year, and whether "PDZ Domains" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "PDZ Domains" by people in Profiles.
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Structural basis of coronavirus E protein interactions with human PALS1 PDZ domain. Commun Biol. 2021 06 11; 4(1):724.
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SARS-CoV-2 Envelope (E) protein interacts with PDZ-domain-2 of host tight junction protein ZO1. PLoS One. 2021; 16(6):e0251955.
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Host PDZ-containing proteins targeted by SARS-CoV-2. FEBS J. 2021 09; 288(17):5148-5162.
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Comparing the binding properties of peptides mimicking the Envelope protein of SARS-CoV and SARS-CoV-2 to the PDZ domain of the tight junction-associated PALS1 protein. Protein Sci. 2020 10; 29(10):2038-2042.
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Functional Pangenome Analysis Shows Key Features of E Protein Are Preserved in SARS and SARS-CoV-2. Front Cell Infect Microbiol. 2020; 10:405.
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Impact of Azidohomoalanine Incorporation on Protein Structure and Ligand Binding. Chembiochem. 2017 12 05; 18(23):2340-2350.
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The PDZ-binding motif of severe acute respiratory syndrome coronavirus envelope protein is a determinant of viral pathogenesis. PLoS Pathog. 2014 Aug; 10(8):e1004320.
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Biophysical characterization of the complex between human papillomavirus E6 protein and synapse-associated protein 97. J Biol Chem. 2011 Feb 04; 286(5):3597-606.