"Zinc Fingers" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.
| Descriptor ID |
D016335
|
| MeSH Number(s) |
G02.111.570.820.709.275.500.985
|
| Concept/Terms |
Zinc Fingers- Zinc Fingers
- Finger, Zinc
- Fingers, Zinc
- Zinc Finger
- Zinc Finger Motifs
- Motif, Zinc Finger
- Motifs, Zinc Finger
- Zinc Finger Motif
|
Below are MeSH descriptors whose meaning is more general than "Zinc Fingers".
Below are MeSH descriptors whose meaning is more specific than "Zinc Fingers".
This graph shows the total number of publications written about "Zinc Fingers" by people in this website by year, and whether "Zinc Fingers" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2005 | 1 | 1 | 2 |
| 2006 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 2 | 2 | 4 |
| 2018 | 0 | 4 | 4 |
| 2020 | 0 | 2 | 2 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Zinc Fingers" by people in Profiles.
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Analyzing master regulators and scRNA-seq of COVID-19 patients reveals an underlying anti-SARS-CoV-2 mechanism of ZNF proteins. Brief Bioinform. 2021 09 02; 22(5).
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Structure and Function of N-Terminal Zinc Finger Domain of SARS-CoV-2 NSP2. Virol Sin. 2021 Oct; 36(5):1104-1112.
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Structural analysis of viral ExoN domains reveals polyphyletic hijacking events. PLoS One. 2021; 16(3):e0246981.
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The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2. J Virol. 2020 11 09; 94(23).
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1H, 13C, and 15N backbone chemical shift assignments of coronavirus-2 non-structural protein Nsp10. Biomol NMR Assign. 2021 04; 15(1):65-71.
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Crystal Structure of Non-Structural Protein 10 from Severe Acute Respiratory Syndrome Coronavirus-2. Int J Mol Sci. 2020 Oct 06; 21(19).
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Zinc finger and interferon-stimulated genes play a vital role in TB-IRIS following HAART in AIDS. Per Med. 2018 07 01; 15(4):251-269.
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ZNF341 controls STAT3 expression and thereby immunocompetence. Sci Immunol. 2018 06 15; 3(24).
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A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity. Sci Immunol. 2018 06 15; 3(24).
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Utrophin up-regulation by artificial transcription factors induces muscle rescue and impacts the neuromuscular junction in mdx mice. Biochim Biophys Acta Mol Basis Dis. 2018 Apr; 1864(4 Pt A):1172-1182.