"Amino Acid Substitution" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
| Descriptor ID |
D019943
|
| MeSH Number(s) |
E05.393.420.601.035 G05.558.109
|
| Concept/Terms |
Amino Acid Substitution- Amino Acid Substitution
- Amino Acid Substitutions
- Substitution, Amino Acid
- Substitutions, Amino Acid
|
Below are MeSH descriptors whose meaning is more general than "Amino Acid Substitution".
Below are MeSH descriptors whose meaning is more specific than "Amino Acid Substitution".
This graph shows the total number of publications written about "Amino Acid Substitution" by people in this website by year, and whether "Amino Acid Substitution" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 3 | 3 |
| 1999 | 0 | 2 | 2 |
| 2002 | 0 | 2 | 2 |
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 4 | 5 |
| 2005 | 2 | 12 | 14 |
| 2006 | 3 | 5 | 8 |
| 2007 | 1 | 9 | 10 |
| 2008 | 1 | 5 | 6 |
| 2009 | 0 | 7 | 7 |
| 2010 | 0 | 6 | 6 |
| 2011 | 0 | 4 | 4 |
| 2012 | 0 | 4 | 4 |
| 2013 | 0 | 4 | 4 |
| 2014 | 1 | 4 | 5 |
| 2015 | 0 | 4 | 4 |
| 2016 | 2 | 4 | 6 |
| 2017 | 12 | 70 | 82 |
| 2018 | 10 | 77 | 87 |
| 2019 | 4 | 12 | 16 |
| 2020 | 3 | 11 | 14 |
| 2021 | 7 | 24 | 31 |
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Below are the most recent publications written about "Amino Acid Substitution" by people in Profiles.
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The virological impacts of SARS-CoV-2 D614G mutation. J Mol Cell Biol. 2021 12 30; 13(10):712-720.
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Limited Neutralization of Authentic Severe Acute Respiratory Syndrome Coronavirus 2 Variants Carrying E484K In Vitro. J Infect Dis. 2021 10 13; 224(7):1109-1114.
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SARS-CoV-2 escape from a highly neutralizing COVID-19 convalescent plasma. Proc Natl Acad Sci U S A. 2021 09 07; 118(36).
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Characterization of the emerging B.1.621 variant of interest of SARS-CoV-2. Infect Genet Evol. 2021 11; 95:105038.
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Evolutionary analysis of the Delta and Delta Plus variants of the SARS-CoV-2 viruses. J Autoimmun. 2021 11; 124:102715.
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Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies. PLoS Pathog. 2021 08; 17(8):e1009772.
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Deep geometric representations for modeling effects of mutations on protein-protein binding affinity. PLoS Comput Biol. 2021 08; 17(8):e1009284.
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The mutation that helps Delta spread like wildfire. Nature. 2021 08; 596(7873):472-473.
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Rise and Fall of SARS-CoV-2 Lineage A.27 in Germany. Viruses. 2021 07 29; 13(8).
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D614G Substitution of SARS-CoV-2 Spike Protein Increases Syncytium Formation and Virus Titer via Enhanced Furin-Mediated Spike Cleavage. mBio. 2021 08 31; 12(4):e0058721.