Receptor, Interferon alpha-beta
"Receptor, Interferon alpha-beta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitously expressed heterodimeric receptor that is specific for both INTERFERON-ALPHA and INTERFERON-BETA. It is composed of two subunits referred to as IFNAR1 and IFNAR2. The IFNAR2 subunit is believed to serve as the ligand-binding chain; however both chains are required for signal transduction. The interferon alpha-beta receptor signals through the action of JANUS KINASES such as the TYK2 KINASE.
| Descriptor ID |
D053633
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| MeSH Number(s) |
D12.776.543.750.705.852.400.500
|
| Concept/Terms |
Receptor, Interferon alpha-beta- Receptor, Interferon alpha-beta
- Receptor, Interferon alpha beta
- IFN-alphaR
- Interferon alpha Receptor
- alpha Receptor, Interferon
- Type I Interferon Receptor
- Interferon alpha-beta Receptor
- Interferon alpha beta Receptor
- Interferon alphabeta Receptors
- Receptors, Interferon alphabeta
- Receptor, Interferon alpha
- IFN-alphabetaR
- IFN alphabetaR
- Interferon alpha Receptors
- Receptors, Interferon alpha
- alpha Receptors, Interferon
Interferon alpha-beta Receptor Chain 2- Interferon alpha-beta Receptor Chain 2
- Interferon alpha beta Receptor Chain 2
- Interferon alpha-beta Receptor IFNAR2 Subunit
- Interferon alpha beta Receptor IFNAR2 Subunit
- Interferon alpha-beta Receptor-2
- Interferon alpha beta Receptor 2
- Receptor-2, Interferon alpha-beta
- alpha-beta Receptor-2, Interferon
- IFNAR2 Subunit, Interferon alpha-beta Receptor
- IFNAR2 Subunit, Interferon alpha beta Receptor
Interferon alpha-beta Receptor Chain 1- Interferon alpha-beta Receptor Chain 1
- Interferon alpha beta Receptor Chain 1
- Interferon alpha-beta Receptor IFNAR1 Subunit
- Interferon alpha beta Receptor IFNAR1 Subunit
- Interferon alpha-beta Receptor-1
- Interferon alpha beta Receptor 1
- Receptor-1, Interferon alpha-beta
- alpha-beta Receptor-1, Interferon
- IFNAR1 Subunit, Interferon alpha-beta Receptor
- IFNAR1 Subunit, Interferon alpha beta Receptor
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Below are MeSH descriptors whose meaning is more general than "Receptor, Interferon alpha-beta".
Below are MeSH descriptors whose meaning is more specific than "Receptor, Interferon alpha-beta".
This graph shows the total number of publications written about "Receptor, Interferon alpha-beta" by people in this website by year, and whether "Receptor, Interferon alpha-beta" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 2 | 2 |
| 2016 | 0 | 2 | 2 |
| 2017 | 5 | 7 | 12 |
| 2018 | 4 | 14 | 18 |
| 2019 | 1 | 3 | 4 |
| 2020 | 0 | 4 | 4 |
| 2021 | 1 | 5 | 6 |
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Below are the most recent publications written about "Receptor, Interferon alpha-beta" by people in Profiles.
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SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway. J Virol. 2021 09 09; 95(19):e0086221.
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Loss-of-function mutations in IFNAR2 in COVID-19 severe infection susceptibility. J Glob Antimicrob Resist. 2021 09; 26:239-240.
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Integrative genomics analysis reveals a 21q22.11 locus contributing risk to COVID-19. Hum Mol Genet. 2021 06 17; 30(13):1247-1258.
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Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities. Cell Rep. 2021 05 18; 35(7):109126.
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Double stranded RNA drives anti-viral innate immune responses, sickness behavior and cognitive dysfunction dependent on dsRNA length, IFNAR1 expression and age. Brain Behav Immun. 2021 07; 95:413-428.
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Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19. Nat Med. 2021 04; 27(4):668-676.
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Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine. J Exp Med. 2021 04 05; 218(4).
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Global absence and targeting of protective immune states in severe COVID-19. Nature. 2021 03; 591(7848):124-130.
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mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2. PLoS Pathog. 2020 12; 16(12):e1009163.
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Genetic mechanisms of critical illness in COVID-19. Nature. 2021 03; 591(7848):92-98.