"Thrombospondin 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An extracellular matrix glycoprotein from platelets and a variety of normal and transformed cells of both mesenchymal and epithelial origin. Thrombospondin-1 is believed to play a role in cell migration and proliferation, during embryogenesis and wound repair. Also, it has been studied for its use as a potential regulator of tumor growth and metastasis.
| Descriptor ID |
D019700
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| MeSH Number(s) |
D12.776.395.550.895.800 D12.776.543.550.895.800
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Thrombospondin 1".
Below are MeSH descriptors whose meaning is more specific than "Thrombospondin 1".
This graph shows the total number of publications written about "Thrombospondin 1" by people in this website by year, and whether "Thrombospondin 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 2 | 2 |
| 2018 | 1 | 1 | 2 |
| 2021 | 0 | 2 | 2 |
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Below are the most recent publications written about "Thrombospondin 1" by people in Profiles.
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Type 2 Diabetes Coagulopathy Proteins May Conflict With Biomarkers Reflective of COVID-19 Severity. Front Endocrinol (Lausanne). 2021; 12:658304.
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ADAMTS13 regulation of VWF multimer distribution in severe COVID-19. J Thromb Haemost. 2021 08; 19(8):1914-1921.
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microRNA-222 Attenuates Mitochondrial Dysfunction During Transmissible Gastroenteritis Virus Infection. Mol Cell Proteomics. 2019 01; 18(1):51-64.
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ADAMTS13 Deficiency Shortens the Life Span of Mice With Experimental Diabetes. Diabetes. 2018 10; 67(10):2069-2083.
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Thrombospondin-1 protects against pathogen-induced lung injury by limiting extracellular matrix proteolysis. JCI Insight. 2018 02 08; 3(3).
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New methodologies to accurately assess circulating active transforming growth factor-ß1 levels: implications for evaluating heart failure and the impact of left ventricular assist devices. Transl Res. 2018 02; 192:15-29.
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Bone morphogenetic protein 4 regulates microRNAs miR-494 and miR-126-5p in control of endothelial cell function in angiogenesis. Thromb Haemost. 2017 04 03; 117(4):734-749.
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What mediates the effects of thrombospondin-1 in pulmonary hypertension? New evidence for a dual-pronged role of CD47. Cardiovasc Res. 2017 01; 113(1):3-5.
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SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-ß1 via ROS/p38 MAPK/STAT3 pathway. Sci Rep. 2016 05 13; 6:25754.