Unfolded Protein Response
"Unfolded Protein Response" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS.
| Descriptor ID |
D056811
|
| MeSH Number(s) |
G02.111.660.871.790.600.962 G02.111.691.600.850 G03.734.871.790.600.850 G05.308.670.600.850
|
| Concept/Terms |
Unfolded Protein Response- Unfolded Protein Response
- Protein Response, Unfolded
- Protein Responses, Unfolded
- Response, Unfolded Protein
- Responses, Unfolded Protein
- Unfolded Protein Responses
|
Below are MeSH descriptors whose meaning is more general than "Unfolded Protein Response".
Below are MeSH descriptors whose meaning is more specific than "Unfolded Protein Response".
This graph shows the total number of publications written about "Unfolded Protein Response" by people in this website by year, and whether "Unfolded Protein Response" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 0 | 1 | 1 |
| 2017 | 5 | 4 | 9 |
| 2018 | 3 | 9 | 12 |
| 2019 | 2 | 0 | 2 |
| 2020 | 0 | 2 | 2 |
| 2021 | 1 | 1 | 2 |
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Below are the most recent publications written about "Unfolded Protein Response" by people in Profiles.
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Endoplasmic reticulum stress and NF-kB activation in SARS-CoV-2 infected cells and their response to antiviral therapy. IUBMB Life. 2022 01; 74(1):93-100.
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Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs. Mol Cell Proteomics. 2021; 20:100120.
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Manipulation of the unfolded protein response: A pharmacological strategy against coronavirus infection. PLoS Pathog. 2021 06; 17(6):e1009644.
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Autophagy, Unfolded Protein Response, and Neuropilin-1 Cross-Talk in SARS-CoV-2 Infection: What Can Be Learned from Other Coronaviruses. Int J Mol Sci. 2021 Jun 01; 22(11).
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Induction of the Proinflammatory Chemokine Interleukin-8 Is Regulated by Integrated Stress Response and AP-1 Family Proteins Activated during Coronavirus Infection. Int J Mol Sci. 2021 May 26; 22(11).
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Glucose-regulated protein (GRP78) is an important cell surface receptor for viral invasion, cancers, and neurological disorders. IUBMB Life. 2021 06; 73(6):843-854.
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The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection. J Biol Chem. 2021 Jan-Jun; 296:100759.
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The Unfolded Protein Response and Autophagy on the Crossroads of Coronaviruses Infections. Front Cell Infect Microbiol. 2021; 11:668034.
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Obesity as a Risk Factor for Severe COVID-19 and Complications: A Review. Cells. 2021 04 17; 10(4).
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Noncoding RNAs: modulators and modulatable players during infection-induced stress response. Brief Funct Genomics. 2021 03 02; 20(1):28-41.