"Sterol 14-Demethylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI; and protozoa.
| Descriptor ID |
D058886
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| MeSH Number(s) |
D08.244.453.878.500 D08.244.453.915.880 D08.811.682.690.708.170.499.500 D08.811.682.690.708.170.915.880 D12.776.422.220.453.878.500 D12.776.422.220.453.915.880
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| Concept/Terms |
Sterol 14-Demethylase- Sterol 14-Demethylase
- 14-Demethylase, Sterol
- Sterol 14 Demethylase
- Sterol 14-alpha-Demethylase
- 14-alpha-Demethylase, Sterol
- Sterol 14 alpha Demethylase
- Lanosterol 14 alpha-Demethylase
- 14 alpha-Demethylase, Lanosterol
- Lanosterol 14 alpha Demethylase
- CYP51 Cytochrome P-450
- CYP51 Cytochrome P 450
- Cytochrome P-450, CYP51
- P-450, CYP51 Cytochrome
- Eburicol 14alpha-Demethylase
- 14alpha-Demethylase, Eburicol
- Eburicol 14alpha Demethylase
- Obtusifoliol 14alpha-Demethylase
- 14alpha-Demethylase, Obtusifoliol
- Obtusifoliol 14alpha Demethylase
- Cytochrome P-450 CYP51
- CYP51, Cytochrome P-450
- Cytochrome P 450 CYP51
- P-450 CYP51, Cytochrome
- Sterol 14-Demethylases
- 14-Demethylases, Sterol
- Sterol 14 Demethylases
- Eburicol 14 alpha-Demethylase
- 14 alpha-Demethylase, Eburicol
- Eburicol 14 alpha Demethylase
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Below are MeSH descriptors whose meaning is more general than "Sterol 14-Demethylase".
Below are MeSH descriptors whose meaning is more specific than "Sterol 14-Demethylase".
This graph shows the total number of publications written about "Sterol 14-Demethylase" by people in this website by year, and whether "Sterol 14-Demethylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 0 | 1 | 1 |
| 2017 | 0 | 2 | 2 |
| 2018 | 1 | 1 | 2 |
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Below are the most recent publications written about "Sterol 14-Demethylase" by people in Profiles.
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Magnitude of Voriconazole Resistance in Clinical and Environmental Isolates of Aspergillus flavus and Investigation into the Role of Multidrug Efflux Pumps. Antimicrob Agents Chemother. 2018 11; 62(11).
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Elevated MIC Values of Imidazole Drugs against Aspergillus fumigatus Isolates with TR34/L98H/S297T/F495I Mutation. Antimicrob Agents Chemother. 2018 05; 62(5).
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4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection. PLoS Negl Trop Dis. 2017 12; 11(12):e0006132.
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Susceptibility Testing of Common and Uncommon Aspergillus Species against Posaconazole and Other Mold-Active Antifungal Azoles Using the Sensititre Method. Antimicrob Agents Chemother. 2017 06; 61(6).
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Synthesis of amino acid appended indoles: appreciable anti-fungal activity and inhibition of ergosterol biosynthesis as their probable mode of action. Eur J Med Chem. 2014 Jun 10; 80:325-39.