Electron Transport Complex I
"Electron Transport Complex I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A flavoprotein and iron sulfur-containing oxidoreductase complex that catalyzes the conversion of UBIQUINONE to ubiquinol. In MITOCHONDRIA the complex also couples its reaction to the transport of PROTONS across the internal mitochondrial membrane. The NADH DEHYDROGENASE component of the complex can be isolated and is listed as EC 1.6.99.3.
| Descriptor ID |
D042967
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| MeSH Number(s) |
D05.500.562.249 D08.811.600.250.500.500 D08.811.682.608.504 D12.776.157.427.374.375.863 D12.776.157.530.450.250.875.300 D12.776.331.199.500 D12.776.543.277.500.500 D12.776.543.585.450.250.875.437 D12.776.556.579.374.375.140
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| Concept/Terms |
NADH Dehydrogenase (Ubiquinone)- NADH Dehydrogenase (Ubiquinone)
- NADH Dehydrogenase Complex 1
- NADH Dehydrogenase I
- NADH DH I
- Ubiquinone Reductase
- NADH-Coenzyme Q Reductase
- NADH Coenzyme Q Reductase
- NADH-CoQ Reductase
- NADH CoQ Reductase
- NADH-Ubiquinone Oxidoreductase
- NADH Ubiquinone Oxidoreductase
- Oxidoreductase, NADH-Ubiquinone
- NADH-Ubiquinone Reductase
- NADH Ubiquinone Reductase
- Reductase, NADH-Ubiquinone
- Rotenone-Sensitive Mitochondrial NADH-Ubiquinone Oxidoreductase
- Rotenone Sensitive Mitochondrial NADH Ubiquinone Oxidoreductase
- Complex I Dehydrogenase
- Dehydrogenase, Complex I
- NADH Q1 Oxidoreductase
- Oxidoreductase, NADH Q1
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Below are MeSH descriptors whose meaning is more general than "Electron Transport Complex I".
Below are MeSH descriptors whose meaning is more specific than "Electron Transport Complex I".
This graph shows the total number of publications written about "Electron Transport Complex I" by people in this website by year, and whether "Electron Transport Complex I" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 4 | 1 | 5 |
| 2018 | 2 | 0 | 2 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Electron Transport Complex I" by people in Profiles.
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Estimates of gene ensemble noise highlight critical pathways and predict disease severity in H1N1, COVID-19 and mortality in sepsis patients. Sci Rep. 2021 05 24; 11(1):10793.
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Measuring Rates of ATP Synthesis. Methods Mol Biol. 2019; 1862:97-107.
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Metabolism-Associated Markers and Childhood Autism Rating Scales (CARS) as a Measure of Autism Severity. J Mol Neurosci. 2018 Jul; 65(3):265-276.
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The idebenone metabolite QS10 restores electron transfer in complex I and coenzyme Q defects. Biochim Biophys Acta Bioenerg. 2018 09; 1859(9):901-908.
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The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury. Nat Commun. 2017 12 12; 8(1):2068.
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In vitro characterization of mitochondrial function and structure in rat and human cells with a deficiency of the NADH: ubiquinone oxidoreductase Ndufc2 subunit. Hum Mol Genet. 2017 12 01; 26(23):4541-4555.
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The lignan manassantin is a potent and specific inhibitor of mitochondrial complex I and bioenergetic activity in mammals. J Biol Chem. 2017 12 22; 292(51):20989-20997.
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Mitochondrial complex I bridges a connection between regulation of carbon flexibility and gastrointestinal commensalism in the human fungal pathogen Candida albicans. PLoS Pathog. 2017 Jun; 13(6):e1006414.
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Novel MT-ND5 gene mutation identified in Leber's hereditary optic neuropathy patient using mitochondrial genome sequencing. J Neurol Sci. 2017 04 15; 375:301-303.