STAT2 Transcription Factor
"STAT2 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signal transducer and activator of transcription that mediates cellular responses to TYPE I INTERFERONS. Stat2 protein is associated constitutively with INTERFERON REGULATORY FACTOR-9. After PHOSPHORYLATION Stat2 forms the IFN-STIMULATED GENE FACTOR 3 COMPLEX to regulate expression of target GENES.
| Descriptor ID |
D050795
|
| MeSH Number(s) |
D12.644.360.024.303.500.750 D12.644.360.024.342.200 D12.776.157.057.061.500.750 D12.776.157.057.186.200 D12.776.260.513.249.750 D12.776.476.024.386.500.750 D12.776.476.024.430.200 D12.776.930.354.249.750 D12.776.930.840.200
|
| Concept/Terms |
STAT2 Transcription Factor- STAT2 Transcription Factor
- Transcription Factor, STAT2
- Transcription Factor STAT2
- Factor STAT2, Transcription
- STAT2 Protein
- Signal Transducer and Activator of Transcription 2
|
Below are MeSH descriptors whose meaning is more general than "STAT2 Transcription Factor".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
- Intracellular Signaling Peptides and Proteins [D12.644.360]
- Adaptor Proteins, Signal Transducing [D12.644.360.024]
- Interferon-Stimulated Gene Factor 3 [D12.644.360.024.303]
- Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.644.360.024.303.500]
- STAT2 Transcription Factor [D12.644.360.024.303.500.750]
- STAT Transcription Factors [D12.644.360.024.342]
- STAT2 Transcription Factor [D12.644.360.024.342.200]
- Proteins [D12.776]
- Carrier Proteins [D12.776.157]
- Adaptor Proteins, Signal Transducing [D12.776.157.057]
- Interferon-Stimulated Gene Factor 3 [D12.776.157.057.061]
- Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.776.157.057.061.500]
- STAT2 Transcription Factor [D12.776.157.057.061.500.750]
- STAT Transcription Factors [D12.776.157.057.186]
- STAT2 Transcription Factor [D12.776.157.057.186.200]
- DNA-Binding Proteins [D12.776.260]
- Interferon-Stimulated Gene Factor 3 [D12.776.260.513]
- Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.776.260.513.249]
- STAT2 Transcription Factor [D12.776.260.513.249.750]
- Intracellular Signaling Peptides and Proteins [D12.776.476]
- Adaptor Proteins, Signal Transducing [D12.776.476.024]
- Interferon-Stimulated Gene Factor 3 [D12.776.476.024.386]
- Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.776.476.024.386.500]
- STAT2 Transcription Factor [D12.776.476.024.386.500.750]
- STAT Transcription Factors [D12.776.476.024.430]
- STAT2 Transcription Factor [D12.776.476.024.430.200]
- Transcription Factors [D12.776.930]
- Interferon-Stimulated Gene Factor 3 [D12.776.930.354]
- Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.776.930.354.249]
- STAT2 Transcription Factor [D12.776.930.354.249.750]
- STAT Transcription Factors [D12.776.930.840]
- STAT2 Transcription Factor [D12.776.930.840.200]
Below are MeSH descriptors whose meaning is more specific than "STAT2 Transcription Factor".
This graph shows the total number of publications written about "STAT2 Transcription Factor" by people in this website by year, and whether "STAT2 Transcription Factor" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 3 | 4 | 7 |
| 2018 | 1 | 4 | 5 |
| 2020 | 2 | 0 | 2 |
| 2021 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "STAT2 Transcription Factor" by people in Profiles.
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SARS-CoV-2 Spike protein enhances ACE2 expression via facilitating Interferon effects in bronchial epithelium. Immunol Lett. 2021 09; 237:33-41.
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SARS-CoV-2 Nonstructural Protein 1 Inhibits the Interferon Response by Causing Depletion of Key Host Signaling Factors. J Virol. 2021 06 10; 95(13):e0026621.
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STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters. Nat Commun. 2020 11 17; 11(1):5838.
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SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling. Proc Natl Acad Sci U S A. 2020 11 10; 117(45):28344-28354.
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Human antibodies targeting Zika virus NS1 provide protection against disease in a mouse model. Nat Commun. 2018 11 01; 9(1):4560.
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Deconvolution of pro- and antiviral genomic responses in Zika virus-infected and bystander macrophages. Proc Natl Acad Sci U S A. 2018 09 25; 115(39):E9172-E9181.
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STAT2-Dependent Immune Responses Ensure Host Survival despite the Presence of a Potent Viral Antagonist. J Virol. 2018 07 15; 92(14).
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Basal interferon signaling and therapeutic use of interferons in controlling rotavirus infection in human intestinal cells and organoids. Sci Rep. 2018 05 29; 8(1):8341.
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An Immunocompetent Mouse Model of Zika Virus Infection. Cell Host Microbe. 2018 05 09; 23(5):672-685.e6.
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Andrographolide inhibits influenza A virus-induced inflammation in a murine model through NF-?B and JAK-STAT signaling pathway. Microbes Infect. 2017 12; 19(12):605-615.