"Presenilin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN1 mutations cause early-onset ALZHEIMER DISEASE type 3 that may occur as early as 30 years of age in humans.
| Descriptor ID |
D053764
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| MeSH Number(s) |
D12.776.543.696.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Presenilin-1".
Below are MeSH descriptors whose meaning is more specific than "Presenilin-1".
This graph shows the total number of publications written about "Presenilin-1" by people in this website by year, and whether "Presenilin-1" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 3 | 3 | 6 |
| 2018 | 2 | 0 | 2 |
| 2019 | 0 | 2 | 2 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Presenilin-1" by people in Profiles.
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Angiotensin converting enzyme 2 is a novel target of the ?-secretase complex. Sci Rep. 2021 05 07; 11(1):9803.
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Transplantation of bone marrow mesenchymal stem cells alleviates spinal cord injury via inhibiting Notch signaling. Eur Rev Med Pharmacol Sci. 2019 Aug; 23(3 Suppl):31-38.
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Peripheral adaptive immunity of the triple transgenic mouse model of Alzheimer's disease. J Neuroinflammation. 2019 Jan 05; 16(1):3.
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Beneficial effect of ovocystatin on the cognitive decline in APP/PS1 transgenic mice. Adv Med Sci. 2019 Mar; 64(1):65-71.
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Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affecting Aß clearance. Free Radic Res. 2018 Dec; 52(11-12):1311-1322.
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Differential effects of alcohol and its metabolite acetaldehyde on vascular smooth muscle cell Notch signaling and growth. Am J Physiol Heart Circ Physiol. 2018 01 01; 314(1):H131-H137.
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Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer's disease. Proc Natl Acad Sci U S A. 2017 12 05; 114(49):13018-13023.
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Altered spontaneous brain activity pattern in cognitively normal young adults carrying mutations of APP, presenilin-1/2 and APOE e4. Eur J Radiol. 2017 Oct; 95:18-23.
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Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (?E9) mice. CNS Neurosci Ther. 2017 Jul; 23(7):590-604.
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Different Hippocampus Functional Connectivity Patterns in Healthy Young Adults with Mutations of APP/Presenilin-1/2 and APOEe4. Mol Neurobiol. 2018 Apr; 55(4):3439-3450.